Individualized Neuromodulation Intervention Techniques for the Core Clinical Features of Drug Addiction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Stop-signal reaction time (SSRT) from the stop-signal task
研究概览
简要总结
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy with traditional open-loop tACS methods.
详细描述
The current study delineates a robust correlation between prefrontal cortex EEG signals and the psychological craving associated with methamphetamine usage. Dependents exhibit heightened β oscillation energy in the MPFC region and diminished γ oscillation energy across the DLPFC-MPFC region. Previously, through the implementation of rTMS interventions on the left DLPFC, the investigators have successfully reduced the craving levels in users when exposed to relevant cues, coupled with observed decreases in β oscillation energy and increases in γ oscillation energy in the MPFC region. This indicates that both β and γ oscillation energies are instrumental in representing the involvement of MPFC and DLPFC during craving episodes, and neuromodulatory technologies can modulate these energy levels, consequently reducing cravings. Furthermore, the investigators identified a significant augmentation in the theta energy in the occipital lobe when MA dependents are confronted with drug-related cue imagery, signifying a potential crucial neural marker for addiction-induced brain activity. Therefore, the investigators intend to employ the non-invasive transcranial alternating current stimulation (tACS) technique, predicated upon biomarkers of addiction states, to administer specific frequency stimulations to targeted brain regions, aiming to achieve therapeutic objectives in addiction treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals aged between 18 and 55 years, irrespective of gender, having completed a minimum of 9 years of education or capable of effectively cooperating in questionnaire and behavioral task evaluations.
- •Meet the diagnostic criteria set forth by the DSM-5 concerning the severity of amphetamine-type substance addiction.
- •A history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use being at least once per week.
- •Consent to actively cooperate in the completion of subsequent follow-up assessments.
排除标准
- •Severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an IQ score less than
- •A diagnosis of schizophrenia or other severe mental illnesses as per the DSM-5 criteria.
- •Abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years.
- •Severe organic diseases that might compromise study participation.
- •Contraindications to tACS, such as a history of epileptic seizures or the presence of metallic implants in proximity to the head.
研究组 & 干预措施
Closed-loop tACS stimulation based on addiction-induced states
Participants will receive closed-loop tACS interventions at different frequencies, with a 5-day interval between sessions. During each session, participants will be exposed to MA-related cue paradigms to induce cue-reactivity states, while scalp EEG signals are collected. Stimulation will be triggered only when specific EEG signals associated with MA cues are identified. The optimal frequency will be determined at the group level based on prespecified cue-reactivity EEG and inhibitory-control outcomes. Subsequently, participants will receive two additional control conditions at the identified optimal frequency: random-time stimulation, which will deliver the same number of stimulation events at pseudorandom time points independently of the EEG-defined brain state, and open-loop continuous stimulation, which will deliver an equivalent total stimulation dose continuously.
干预措施: Closed-loop tACS stimulation based on addiction-induced states (Device)
结局指标
主要结局
Stop-signal reaction time (SSRT) from the stop-signal task
时间窗: Through study completion, an average of 1 month
The stop-signal task can indicate executive control capabilities by measuring Stop-signal reaction time. A shorter SSRT indicates better inhibitory functions.
次要结局
- Changes of electroencephalogram power spectrum(Through study completion, an average of 1 month)
- Changes of electroencephalogram power spectrum(through study completion, an average of 1 month)