Prevention of COPD exacerbation by normalizing serum vitamin D3 level.
- Conditions
- Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary disease with acute exacerbation, unspecified
- Registration Number
- IRCT2016022826816N1
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion criterial: All COPD patients including those with emphysema and chronic bronchitis with serum vitamin D-25 level less than 75 nmol/L.
Exclusion criterial: 1. patients younger than 40 yrs; 2. patients with FEV1/FVC < 70%; 3. patients that after inhalation of 400 microgra salbutamol have FEV1/FVC > 70%; 4. patients with history of consumtion of less than 15 pack year cigarettes; 5. patient with asthma or history of asthma; 6. patients with serum level of vitamine D > 75 mnol/L; 7. patients with diabetes, renal failure, history of MI, bronchiectasia, sarcoidosis, hypoparathyroidism, nephrolithiasis, active TB, liver failure, malignancy with remission less than 3 years age; 8. patients under treatment with carbamazepine, cardiac glycosides, phenobarbital, phenytoin, perimidon; 9. patients with serum calcium level above 2.65 mmol/L or serum creatinine level above 125 micromol/L; 10. patients unable to cooperate with spirometery; 11. patient who need to receive more than 12 hrs per day oxygen.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Occurance of an exacerbation of COPD. Timepoint: Monthly. Method of measurement: clinical and paraclinical observations.
- Secondary Outcome Measures
Name Time Method Functional class of the patients. Timepoint: End of the study. Method of measurement: clinical observation and interview.