Tackling underdiagnosis of Large Artery Giant Cell Arteritis: a prevalence and phenotype study.

Completed

Conditions: giant cell arteritis
large vessel vasculitis
10047066

Registration Number: NL-OMON35072

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

Giant cell arteritis according to the 1990 ACR classification critieria, or
elevated ESR on 2 separate occasions with a time interval of at least 4 weeks, the elevated ESR is not explained by a chest radiograph, abdominal ultrasound or blood tests (including paraprotein testing)

Exclusion Criteria

The use of corticosteroids or any other systemic immunosuppresant for more than 24 hours at the time of PET-CT scanning. Inability to understand or unwillingness to provide informed consent. A plasma glucose level >11 mmol/l at the time of PET-CT scanning.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Prevalence of large-vessel-vasculitis in patients with temporal arteritis or<br /><br>unexplained prolonged inflammatory response.<br /><br>Diagnostic utility of PET/low-dose-CT in patients with an unexplained prolonged<br /><br>inflammatory response.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Association between large-vessel-vasculitis and clinical/biochemical parameters.<br /><br>Association between large-vessel-vasculitis and inflammation score of temporal<br /><br>artery biopsy.<br /><br>Sensitivity and specificity of temporal artery biopsy for<br /><br>large-vessel-vasculitis.<br /><br>Association between FDG-uptake and vessel wall morphology/lumen morphology.</p><br>