Efficacy of Transcranial direct current stimulation in treatment of obsessive compulsive symptoms in Schizophrenia
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Improvement in YBOCS(Yale brown obsessive compulsive scale ) score compared to baseline after 5 days (10 sessions / 2 sessions per day) and 1 month of intervention.
研究概览
简要总结
This is a double blind sham controlled study to test the efficacy of transcrational direct current stimulation on obsessive compulsive symptoms in schizophrenia. All patients fulfilling the inclusion and exclusion criteria will recruited for the study for a period of one month. The obsessive and compulsive symptoms will be measured using the Yale brown obsessive compulsive scale. the patients functioning will be measured using the social and occupational functioning scale. Their improvement will be measured using the clinical global improvement scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Schizophrenia Patients (ICD -10 Diagnosis ) aged 18-50 years Moderate to severe rating on YBOCS (score of 15 >) Consenting for the study.
- •No change in medications or other add on treatments during the study period.
排除标准
- •â€¢Patient who have undergone tDCS treatment in the last 3 months.
- •â€¢Patients with mental retardation, H/O drug or alcohol dependence, epilepsy and pregnant women.
- •â€¢Patient receiving ECT.
- •â€¢Existence of serious medical/neurological disorder.
- •â€¢Patients who are uncooperative due to the severity of the illness.
- •â€¢Not consenting to participate in the study.
结局指标
主要结局
Improvement in YBOCS(Yale brown obsessive compulsive scale ) score compared to baseline after 5 days (10 sessions / 2 sessions per day) and 1 month of intervention.
时间窗: Baseline | After 5 days of treatment and After 1 month post treatment
次要结局
- Improvement in YBOCS ratings and overall functioning scores using SOFAS (social and occupational functioning) & CGI ( Clinical global impression) at 1 month compared to preintervention scoring.(1 month)