Comparison of the effects and side effects of midazolam, haloperidol and the combination of them in agitated patients
- Conditions
- Restlessness and agitationagitation.
- Registration Number
- IRCT201301199162N8
- Lead Sponsor
- Tehran University Of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 126
Exclusion criteria:Unstable vital signs( systolic blood pressure less than 90mmHg ,pulse rate less than 60 or more than 120/min and level of consciousness lower than agitation);past medical history of seizure;patients with unknown drug poisoning;Severe agitated patients who can not wait for the effect of intramuscular form of drugs;Allergy to midazolam and haloperidol; Closed angle glaucoma; Parkinson disease;Pregnancy and lactation; Myasthenia gravis;Thyrotoxicosis; Bone marrow suppression; Disagreement of patient's relatives on participation in the survey;Patients with coagulotion disorders such as hemophilia whom intramuscular injection is contraindicated; Reversible causes of agitation such as hypoglycemia (blood sugar less than 50),pain due to MI;Prolonged QT in patients ECG (QT >0.44)
18 to 80 years old gitated patients with agitated behavior scale score of more than 28 .
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tranquilization(control of agitation). Timepoint: one hour after drug injection. Method of measurement: by physician with agitated behaviour scale.
- Secondary Outcome Measures
Name Time Method Side effects include:seizure ,extrapyramidal reactions:dystonia,akathisia,tardive dyskinesia,dizziness,neuroleptic malignant syndrom,nausea and vomiting,apnea or respiratory depression,pain in site of injection,cardiorespiratory arest. Timepoint: 30,60,120 min after drug injection. Method of measurement: physician 's examination and also checking vital signs.