Comparison of effect of levobupivacaine versus Ropivacaine on Pulmonary function in patients undergoing Laparoscopic Cholecystectomy under Segmental Thoracic Spinal Anaesthesia

The study will be conducted at DR S N Medical College and associated groups of hospitals after seeking clearance from the institutional ethical committee and obtaining written informed consent from the patients. To ensure inclusion in the study, each patient will be subjected to a detailed pre-anaesthetic evaluation (PAE) based on a detailed history from the patient and a thorough physical examination as well as a preanesthetic airway assessment. The purpose and detailed procedure will be explained to the patients. We will measure the weight and height of each patient to obtain the exact BMI. Written informed consent will be obtained from all the patients regarding the procedure. Baseline investigations will be done in all the patients to rule out any abnormalities. Visual analogue scale (VAS) and demonstration of the correct usage of the spirometry device to the patient will be explained to all the patients in PAE during the pre-anesthetic visit. The evening before surgery, patients will be instructed to use the spirometer to simulate testing. All patients will be kept nil by mouth as per standard guidelines before the scheduled time of surgery. In the sitting position, either of the drugs will be aseptically administered through a 25G Quincke spinal needle by a midline approach between T8-T9 / T9 T10 intervertebral space. After the free flow of cerebrospinal fluid will be verified, local anaesthetic was given over 15 seconds, without aspiration. The anesthesiologist performing the spinal anaesthesia will be not aware of group allocation. A separate independent anesthesiologist will prepare all local anaesthetic solutions. Immediately after administration of spinal anaesthesia, the patients will be turned to a supine position.