Diagnosis of Intracranial Hypertension Using TCCD, ONSD and ODH by Bedside Ultrasound
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 64
- 主要终点
- Sensitivity and specificity of TCCD
研究概览
简要总结
The goal of this observational study is to investigate several means of measuring intracranial pressure (ICP) non-invasively in patients who had head trauma and received implantation of invasive ICP monitor device. The main questions it aims to answer are:
What are the diagnostic efficacies of Transcranial Color-Coded Doppler Ultrasound (TCCD), Optic Nerve Sheath Diameter (ONSD) and Optic Disc Height (ODH) (the 3 non-invasive way of measuring ICP) compared with invasive ICP monitor? Participants will receive simultaneous non-invasive measurements of TCCD, ONSD and ODH along with during the days of invasive ICP monitoring. The data will be compared among the techniques to study the diagnostic efficacy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Traumatic brain injury;
- •Received invasive ICP monitoring;
- •age ≥ 18 years old.
排除标准
- •Severe eyeball / eyelid damage prevents transorbital ultrasound examination;
- •Allergy to ultrasound coupling agent;
- •Pregnant or lactating females.
结局指标
主要结局
Sensitivity and specificity of TCCD
时间窗: Day 0 (when invasive ICP probe is implanted) to day 10
Sensitivity and specificity of diagnosing intracranial hypertension using TCCD
Sensitivity and specificity of ONSD
时间窗: Day 0 (when invasive ICP probe is implanted) to day 10
Sensitivity and specificity of diagnosing intracranial hypertension using ONSD
Sensitivity and specificity of ODH
时间窗: Day 0 (when invasive ICP probe is implanted) to day 10
Sensitivity and specificity of diagnosing intracranial hypertension using ODH
次要结局
- Pearson correlation coefficient between ultrasound metrics and invasive ICP(Day 0 (when invasive ICP probe is implanted) to day 10)
研究者
Jinfang Liu, MD
Director of the Neurotrauma and Neurointensive Care Group
Xiangya Hospital of Central South University