NCT01906411已完成不适用
Dopaminergic Function and Food Reward
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Differential brain functions in the dopaminergic reward system
研究概览
简要总结
The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.
This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •fMRI contraindications
- •claustrophobia
结局指标
主要结局
Differential brain functions in the dopaminergic reward system
时间窗: 4 hours after intake of the dopamine depletion or balanced aminoacid drink
differential brain fuctions will be measured by blood oxygen level dependent effect.
次要结局
- amino acid level changes due to dopamine depletion(4 hours after intake of the dopamine depletion or balanced aminoacid drink)
研究者
Sabine Frank
Dr.
University Hospital Tuebingen
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use DisordersAlcohol Use DisorderNCT02094196Technische Universität Dresden60
已完成
不适用
The Chocolate Study 2.0Normal WeightNCT04037020USDA Grand Forks Human Nutrition Research Center20
Unknown
不适用
Food Reward Circuit Change by OrthodonticsEating DisordersEating BehaviorEating HabitOrthodontic Appliance ComplicationNCT05026411Bezmialem Vakif University20
已完成
不适用
Dopamine and Opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward ImpulsivityAddictionNCT02557984University of Zurich121
已完成
早期 1 期
Reward and Drug Effects on Mood and Brain ResponseCannabis UseHealthyNCT04512365University of Illinois at Chicago141