Expanded Access Program for Maraviroc At Multiple Centers
- Registration Number
- NCT00426660
- Lead Sponsor
- ViiV Healthcare
- Brief Summary
To provide access to maraviroc to patients who have limited or no therapeutic treatment options and to collect more safety data in a broader patient population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1047
- Subjects must be failing to achieve adequate virologic suppression on their current regimen and have HIV-1 RNA greater than or equal to 1000 copies/ml, at screening
- Have only R5 HIV-1 at Screening as verified by the Monogram Biosciences Trofile assay
- Minimum age must be 16 years or minimum adult age as determined by local regulatory authorities or directed by local law.
- Failed prior treatment with any CCR5 antagonist, in any ongoing CCR5 trial or having previously prematurely discontinued Maraviroc in trials
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 1 maraviroc -
- Primary Outcome Measures
Name Time Method Percentage of Participants With Grade 3 and Grade 4 Adverse Events (AE) Baseline up to Week 144 AEs as defined by the Division of AIDS (DAIDS) toxicity grading scale: Grade 3 = severe: interrupted usual daily activity and traditionally required systemic drug therapy or other treatment. Grade 4 = very severe: events that were unacceptable and intolerable or were irreversable or caused imminent danger of death. If same participant had more than 1 occurrence in the same preferred term event category, only the most severe (grade 4) occurrence was taken. Treatment-related = investigator assessment of a reasonable possibility that the investigational product caused or contributed to the AE.
Percentage of Participants With Grade 3 Laboratory Abnormalities Without Regards to Baseline Abnormalities Baseline up to Week 144 Laboratory abnormalities as defined by the Division of AIDS (DAIDS) toxicity grading scale: Grade 3, Severe =events that interrupted participants usual daily activity and traditionally required systemic drug therapy or other treatment.
Percentage of Participants With Grade 4 Laboratory Abnormalities Without Regards to Baseline Abnormalities Baseline up to Week 144 Laboratory abnormalities as defined by the Division of AIDS (DAIDS) toxicity grading scale: Grade 4, Very Severe = events which were unacceptable and intolerable or were irreversible or caused the participant to be in imminent danger of death.
Percentage of Participants With Acquired Immunodeficiency Syndrome (AIDS)-Defining Illnesses Baseline up to Week 144 Treatment-emergent AIDS-defining opportunistic illnesses based on investigator classification guided by a predefined list of clinical Category C adverse events per Center for Disease Control (CDC) HIV Classification System. Includes events occurring up to 30 days after last dose of study drug.
Percentage of Participants With Possible Acquired Immunodeficiency Syndrome (AIDS) Related Infections and Malignancies by Baseline Viral Load Baseline up to Week 144 Percentage of Participants With Possible Acquired Immunodeficiency Syndrome (AIDS) Related Infections and Malignancies by Baseline/Nadir CD4 Cell Counts Baseline up to Week 144 Percentage of Participants With Possible Acquired Immunodeficiency Syndrome (AIDS) Related Infections and Malignancies by Time on Therapy Baseline up to Week 144 Percentage of Participants With All Causality Treatment-emergent Adverse (AEs) Events by Gender Baseline up to Week 144 Treatment-emergent AEs by gender that occurred up to 30 days after the last dose of study medication.
Percentage of Participants With Treatment-emergent Adverse Events (AEs) by Race Baseline up to Week 144 Treatment-emergent AEs by race that occurred up to 30 days after the last dose of study medication.
Percentage of Participants With Treatment-emergent Adverse Events (AEs) by Age Baseline up to Week 144 Treatment-emergent AEs by age that occurred up to 30 days after the last dose of study medication.
Percentage of Participants With Treatment-emergent Averse Events (AEs) by Baseline Hepatitis B and Hepatitis C Virus Serology Status Baseline up to Week 144 Treatment emergent AEs by hepatis B and hepatitis C serology status that occurred up to 30 days post last dose.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With ≥0.5 log10 Reduction From Baseline in Human Immunodeficiency Virus 1 Ribonucleic Acid (HIV 1 RNA) Baseline up to Week 144 Defined as HIV-1 RNA levels \< 400 Copies/mL or at least 0.5 Log 10-decrease from baseline in HIV-1 RNA levels.
Baseline value calculated as average of the screening and baseline values if both values were within 1 log10 difference.Percentage of Participants With ≥1.0 log10 Reduction From Baseline in HIV 1 RNA Baseline up to Week 144 Defined as HIV-1 RNA levels \< 400 copies/mL or at least 1.0 Log 10-decrease from baseline in HIV-1 RNA levels. Baseline value calculated as average of the screening and baseline values if both values were within 1 log10 difference.
Percentage of Participants With HIV-1 RNA Levels Below the Limit of Quantification: <400 Copies/mL Baseline up to Week 144 Limit of quantification defined as \<400 copies/mL. Baseline value calculated as average of the screening and baseline values if both values were within 1 log 10 difference.
Percentage of Participants With HIV-1 RNA Levels Below the Limit of Quantification: <50 Copies/mL Baseline up to Week 144 Limit of quantification defined as \<50 copies/mL. Baseline value calculated as average of the screening and baseline values if both values were within 1 log 10 difference.
Change From Baseline in CD4 Cell Count Baseline up to Week 144 Change from baseline in cluster of differentiation 4 helper T cells (CD4) cell count. If baseline value was not available, it was taken from immediate preceding non-missing value.
Change From Baseline in CD4 Cell Count Percent Baseline up to Week 144 Change from baseline in CD4 cell count percent . If baseline value was not available, it was taken from immediate preceding non-missing value.
Change From Baseline in CD8 Cell Count Baseline up to Week 144 Change from baseline in cluster of differentiation 8 suppressor T cells (CD8) cell count. If baseline value was not available, it was taken from immediate preceding non-missing value.
Change From Baseline in CD8 Cell Count Percent Baseline up to Week 144 Change from baseline in CD8 cell count percent . If baseline value was not available, it was taken from immediate preceding non-missing value.
Median Time to Virologic Failure Day 1 up to Week 144 Computed as time from the first dose of study medication to the loss of virologic response. Virologic failure defined as: failure to achieve a reduction from baseline (BL) in HIV 1 RNA ≥ 0.5 log10 copies /mL by the second viral load determination (unless viral load was below the lower limit level of quantification \[LLOQ\]); or a ≥ 0.5 log10 increase from nadir in HIV 1 RNA after achieving a HIV 1 RNA reduction from BL \>0.5 log10 copies/mL; or a HIV 1 RNA level of \>1000 copies/mL after having achieved a HIV 1 RNA level below LLOQ.
Number of Participants With Reduced Maraviroc Susceptibility as Defined by Change From Baseline to Time of Virologic Failure in Inhibitory Concentration of 50% (IC 50) and Presence of Plateau Baseline up to Week 144 Resistance to maravroc in viruses from participants failing therapy with R5 virus was investigated using the in vitro phenotypic (drug susceptibility) assay. The number of participants who failed with R5 virus were assessed successfully for maraviroc susceptibility at Baseline and Last on--treatment (Week 144). Samples were analyzed for change from Baseline to time of virologic failure in IC 50 and presence of plateau. A maximal percent inhibition (MPI) \<95% established as a plateau in inhibition at high concentrations of maraviroc was used to identify viruses which had reduced phenotypic susceptibility to maraviroc.
Number of Participants With Emergence of Resistance to Maraviroc as Defined by Genotypic Changes in the V3 Loop of Glycoprotein 120 (gp 120) Baseline up to Week 144 Virus from participants who experienced virologic failure was analyzed for resistance to maraviroc. Resistance testing was performed on archived samples of participants which were available pre--treatment at time of virologic failure. For participants who met definition of virologic failure during the trial, the sequencing of the V3 loop of HIV--1 viral envelope gp 120 was evaluated to identify any amino acid changes concomitant with decreased susceptibility to maraviroc.
Percentage of Participants With Changes in HIV-1 RNA Level in Participants Meeting the Definition of Virologic Failure Baseline up to Week 144 Reasons for virologic failure: A) failure to achieve a reduction in HIV-1 RNA\>=0.5 log10 copies/ml from baseline (BL) by second viral load determination (unless below level of quantification \[LOQ\]); B) \>=0.5 log10 increase from nadir in HIV-1 RNA after achieving an HIV-1 RNA reduction from BL \>0.5 log10 copies/ml ; C) HIV-1 RNA \>1000 copies/ml after having achieved an HIV-1 RNA below LOQ.
Percentage of Participants With Change in Chemokine Co-receptor Tropism From Screening to Time of Virologic Failure Screening up to Week 144 Tropism status (CCR5 \[R5\], CXCR4 \[X4\], Dual Mixed \[DM\], or Non-reportable \[NR\]) at Screening (Scr) and time of virologic failure (V fail). Virologic failure defined as: failure to achieve a reduction from baseline (BL) in HIV 1 RNA ≥0.5 log10 copies/mL by second viral load determination (unless viral load was below lower limit level of quantification \[LLOQ\]); or a ≥ 0.5 log10 increase from nadir in HIV 1 RNA after achieving HIV 1 RNA reduction from BL \>0.5 log10 copies/mL; or a HIV 1 RNA level of \>1000 copies/mL after having achieved a HIV 1 RNA level below LLOQ.
Trial Locations
- Locations (350)
AltaMed Health Services Corporation
🇺🇸Los Angeles, California, United States
Synergy Hematology-Oncology Associates
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
William F. Ehni, MD
🇺🇸Edmonds, Washington, United States
Fenway Community Health
🇺🇸Boston, Massachusetts, United States
Harris County Hospital District
🇺🇸Houston, Texas, United States
Brewton, Gary W MD
🇺🇸Houston, Texas, United States
Diversified Medical Practices, PA
🇺🇸Houston, Texas, United States
Research Access Network
🇺🇸Houston, Texas, United States
Care Resource
🇺🇸Miami, Florida, United States
Health Services Center
🇺🇸Hobson City, Alabama, United States
AHF Research Center
🇺🇸Beverly Hills, California, United States
Kaiser Permanente
🇺🇸Jonesboro, Georgia, United States
Orange County Center for Special Immunology
🇺🇸Fountain Valley, California, United States
Living Hope Clinical Trials
🇺🇸Long Beach, California, United States
Robert Bolan, MD
🇺🇸Los Angeles, California, United States
Maternal-Child and Adolescent Clinic of Infectious Diseases and Virology
🇺🇸Los Angeles, California, United States
Office of Dr. Salah Bibi, MD
🇺🇸Modesto, California, United States
Peter J. Ruane, M.D. Inc.
🇺🇸Los Angeles, California, United States
Erlmed Corp ABA Lim-Keith Muiltispecialty Clinic Inc.
🇺🇸Los Angeles, California, United States
Office of Anthony Mills, MD
🇺🇸Los Angeles, California, United States
Bonnie V Bock MD
🇺🇸Newport Beach, California, United States
Alta Bates Summit Medical Center
🇺🇸Oakland, California, United States
Riverside Medical Clinic
🇺🇸Riverside, California, United States
Desert Medical Group, Clinical Research Center
🇺🇸Palm Springs, California, United States
Bipin Bhagat MD Inc.
🇺🇸Victorville, California, United States
Kaiser Permanente Santa Clara
🇺🇸Santa Clara, California, United States
Shared Medical Research Foundation
🇺🇸Tarzana, California, United States
Kaiser Permanente Colorado
🇺🇸Denver, Colorado, United States
Tarzana Treatment Center
🇺🇸Tarzana, California, United States
Denver Infectious Disease Consultants, PLLC
🇺🇸Denver, Colorado, United States
Kaiser Permanente of Colorado
🇺🇸Lafayette, Colorado, United States
Internal Medicine Associates of Lee County
🇺🇸Fort Myers, Florida, United States
Infectious Disease Research Corp
🇺🇸Boynton Beach, Florida, United States
Comprehensive Care Center
🇺🇸Fort Lauderdale, Florida, United States
Northpoint Medical, PA
🇺🇸Fort Lauderdale, Florida, United States
Office of Gary J. Richmond, MD
🇺🇸Fort Lauderdale, Florida, United States
Donald Johnson, MD
🇺🇸North Miami Beach, Florida, United States
Office of Albert Canas, MD
🇺🇸Miami Beach, Florida, United States
Infectious Diseases Associates, PC
🇺🇸Riverdale, Georgia, United States
Infectious Disease Specialists of Atlanta
🇺🇸Decatur, Georgia, United States
Infectious Disease Consultants
🇺🇸Fairfax, Virginia, United States
Absolute CARE
🇺🇸Atlanta, Georgia, United States
Northstar Medical Center
🇺🇸Chicago, Illinois, United States
Dr.'s Alpert, Trinh, and Posorske
🇺🇸Silver Spring, Maryland, United States
Garden State Infectious Disease Associates, PA
🇺🇸Voorhees, New Jersey, United States
Perion Smith
🇺🇸New York, New York, United States
Schneider Children's Hospital
🇺🇸Great Neck, New York, United States
The Office of Dr. Zale P. Bernstein, MD.
🇺🇸Buffalo, New York, United States
Paul Bellman, MD
🇺🇸New York, New York, United States
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
ID Associates
🇺🇸Gastonia, North Carolina, United States
New York-Presbyterian Hospital
🇺🇸New York, New York, United States
University of Toledo - Health Science Campus
🇺🇸Toledo, Ohio, United States
Lehigh Valley Hospital
🇺🇸Allentown, Pennsylvania, United States
The Office of Dr. Patrick W. Daly, MD.
🇺🇸Dallas, Texas, United States
La Fe CARE Center Clinic
🇺🇸El Paso, Texas, United States
Infectious Diseases Associates of Central Virginia
🇺🇸Danville, Virginia, United States
University Physicians Internal Medicine
🇺🇸Huntington, West Virginia, United States
St. Vincent's Hospital
🇦🇺Darlinghurst, New South Wales, Australia
Infectious Diseases Unit
🇦🇺Adelaide, South Australia, Australia
Centre Hospitalier Universitaire Saint-Pierre, Maladies Infectieuses
🇧🇪Bruxelles, Belgium
Hamilton Health Sciences - McMaster University Medical Centre
🇨🇦Hamilton, Ontario, Canada
Hospital Clínica Universidad Católica
🇨🇱Santiago, RM, Chile
Hospital Clínico San Borja Arriarán
🇨🇱Santiago, RM, Chile
Hopital Europeen George Pompidou
🇫🇷Paris, France
Hopital Tenon, Service des Maladies Infectieuses
🇫🇷Paris, France
Hospital Sungai Buloh
🇲🇾Sungai Buloh, Selangor, Malaysia
Hospital Regional Lic. Adolfo Lopez Mateos
🇲🇽Mexico, DF, Mexico
Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde"
🇲🇽Guadalajara, Jalisco, Mexico
Academisch Ziekenhuis Utrecht
🇳🇱Utrecht, Netherlands
Instituto Nacional de Ciencias Medicas Y Nutricion Dr Salvador Zubiran
🇲🇽Tlalpan, Mexico Df, Mexico
Centro Hospitalar de Cascais
🇵🇹Cascais, Portugal
Centro Ararat Inc
🇵🇷Ponce, Puerto Rico
Spitalul Clinic de Boli Infectioase Constanta
🇷🇴Constanta, Romania
Spitalul Clinic de Boli Infectioase Sf. Parascheva
🇷🇴Iasi, Romania
H. Universitari Germans Trias I Pujol
🇪🇸Badalona, Barcelona, Spain
Hospital Universitari de Bellvitge
🇪🇸Hospitalet de Llobregat, Barcelona, Spain
Hospital de Cabueñes
🇪🇸Cabueñes, Gijon, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital de Basurto
🇪🇸Basurto, Bilbao, Spain
Hospital Clinico Universitario de Santiago de Compostela
🇪🇸Santiago de Compostela, La Coruña, Spain
Hospital Donostia-Donostia Ospitalea
🇪🇸Donostia, San Sebastian, Spain
Hospital Del Mar
🇪🇸Barcelona, Spain
Hospital Universitari Vall D'Hebron
🇪🇸Barcelona, Spain
Hospital de Cruces
🇪🇸Barakaldo, Vizcaya, Spain
Hospital Universitario Virgen de Las Nieves
🇪🇸Granada, Spain
Hospital Puerta Del Mar
🇪🇸Cadiz, Spain
Hospital Universitario San Cecilio
🇪🇸Granada, Spain
Hospital Universitario de La Princesa
🇪🇸Madrid, Spain
Hospital Clinic I Provincial de Barcelona
🇪🇸Barcelona, Spain
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Spain
Hospital General Gregorio Marañon
🇪🇸Madrid, Spain
Hospital Ramon Y Cajal
🇪🇸Madrid, Spain
Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Carlos Iii
🇪🇸Madrid, Spain
Hospital Virgen de La Victoria
🇪🇸Malaga, Spain
Consorcio Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Arnau de Vilanova
🇪🇸Valencia, Spain
Brighton and Sussex University Hospitals NHS Trust, The Elton John Centre
🇬🇧Brighton, Sussex, United Kingdom
Regional Infectious Diseases Unit
🇬🇧Edinburgh, United Kingdom
Ian Charleson Centre
🇬🇧London, United Kingdom
Kaiser Permanente Medical Center
🇺🇸San Francisco, California, United States
Hennepin County Medical Center
🇺🇸Minneapolis, Minnesota, United States
Responsive ID Solutions
🇺🇸San Antonio, Texas, United States
Via Christi Research, Inc.
🇺🇸Wichita, Kansas, United States
Connecticut Health Care Group
🇺🇸Glastonbury, Connecticut, United States
Infectious Disease Clinic
🇺🇸Norwich, Connecticut, United States
CPMC Research Pharmacy
🇺🇸Englewood, New Jersey, United States
Leonia Medical Associates
🇺🇸Englewood, New Jersey, United States
Health for Life Clinic PLLC
🇺🇸Little Rock, Arkansas, United States
UMDNJ
🇺🇸Newark, New Jersey, United States
Prahran Market Clinic
🇦🇺South Yarra, Victoria, Australia
Clinique Medicale du Quartier Latin
🇨🇦Montreal, Quebec, Canada
Queen Elizabeth II Health Sciences Center
🇨🇦Halifax, Nova Scotia, Canada
Thomas T Jefferson, MD
🇺🇸Little Rock, Arkansas, United States
Newark Community Health Center
🇺🇸Newark, New Jersey, United States
Clinical Trials Center
🇺🇸Charleston, West Virginia, United States
Infectious Disease Associates of Memphis
🇺🇸Memphis, Tennessee, United States
FUNCEI
🇦🇷Buenos Aires, Argentina
Instituut voor Tropische Geneeskunde, Inwendige Geneeskunde
🇧🇪Antwerpen, Belgium
Catherine McAuley Centre
🇮🇪Dublin, Ireland
Premier Medical Research Group
🇺🇸Toms River, New Jersey, United States
Physician Clinic
🇲🇾Kota Bharu, Kelantan, Malaysia
Dupont Circle Physicians Group
🇺🇸Washington, District of Columbia, United States
St. James's Hospital
🇮🇪Dublin, Ireland
Hospital Sta. Maria
🇵🇹Lisbon, Portugal
Department of HIV Medicine (I D Clinic), Jaslok Hospital & Research Centre
🇮🇳Mumbai, Maharashtra, India
Department of Infectious Disease, E-Da Hospital
🇨🇳Kaohsiung County, Taiwan
Institutul de Boli Infectioase "Prof. Matei Bals"
🇷🇴Bucuresti, Sector 2, Romania
Hospital de Tortosa Verge de La Cinta
🇪🇸Tortosa, Tarragona, Spain
The University of Alabama
🇺🇸Birmingham, Alabama, United States
Arcispedale S. Anna Azienda Ospedaliera Universitaria di Ferrara
🇮🇹Ferrara, Italy
Unita' Operativa Clinica Malattie Infettive, Dipartimento di Medicina Interna e Malattie Infettive
🇮🇹Genova, Italy
Clinica Malattie Infettive e Tropicali, Universita' degli Studi di Modena Reggio Emilia
🇮🇹Modena, Italy
Unita Operativa di Malattie Infettive e Tropicali
🇮🇹Padova, Italy
Fondazione IRCCS Policlinico S. Matteo
🇮🇹Pavia, Italy
Policlinico Tor Vergata, Divisione Malattie Infettive
🇮🇹Roma, Italy
IRCCS Lazzaro Spallanzani Istituto Nazionale per la Malattie Infettive
🇮🇹Roma, Italy
Reparto di Malattie Infettive, Azienda Sanitaria Locale
🇮🇹Pescara, Italy
IRCCS Lazzaro Spallanzani, Istituto Nazionale per le Malattie Infettive
🇮🇹Roma, Italy
Dipartimento di Malattie Infettive e Tropicali, Universita' di Roma La Sapienza
🇮🇹Roma, Italy
Clinica Universitaria di Malattie Infettive, Ospedale Amedeo di Savoia
🇮🇹Torino, Italy
Uni. Politecnica delle Marche, Ist. Malattie Infettive e Medicina P.
🇮🇹Torrette di Ancona, Italy
Hôpital de la Croix Rousse
🇫🇷Lyon Cedex 04, France
Hopital Saint-Louis
🇫🇷Paris Cedex 10, France
Hopital Bichat-Claude Bernard, Service des Maladies Infectieuses
🇫🇷Paris, France
Hôpital Necker-Service des Maladies Infectieuses et Tropicales
🇫🇷Paris cedex 15, France
Chu Pontchaillou, Service des maladies infectieuses
🇫🇷Rennes, France
Hôpital de la Pitié Salpétrière
🇫🇷Paris, France
Hopital Paul Brousse
🇫🇷Villejuif, France
El Rio, Special Immunology Associates
🇺🇸Tucson, Arizona, United States
Vista Medical
🇺🇸Beverly Hills, California, United States
Quest Clinical Research
🇺🇸San Francisco, California, United States
Infectious Diseases Associates
🇺🇸Sarasota, Florida, United States
All Children's Hospital
🇺🇸St. Petersburg, Florida, United States
Steinhart Medical Associates
🇺🇸Miami, Florida, United States
Daniel Warner M.D., P.A. Consultive Medicine
🇺🇸Daytona Beach, Florida, United States
Osler Medical Inc.
🇺🇸Melbourne, Florida, United States
Therafirst Medical Centers
🇺🇸Ft. Lauderdale, Florida, United States
Sunshine Medical Institute
🇺🇸Hollywood, Florida, United States
Wohlfeiler, Piperato & Associates, LLC
🇺🇸North Miami Beach, Florida, United States
Barry Rodwick, MD
🇺🇸Safety Harbor, Florida, United States
Eric Nicholson, M.D., P.A.
🇺🇸Tallahassee, Florida, United States
Donald Watren MD
🇺🇸West Palm Beach, Florida, United States
Philip Brachman MD
🇺🇸Atlanta, Georgia, United States
University Hepatitis Center at Bach & Godofsky, MD,PA
🇺🇸Sarasota, Florida, United States
Family Health Care of Atlanta
🇺🇸Atlanta, Georgia, United States
Midtown West Medical
🇺🇸Atlanta, Georgia, United States
Ruth M. Rothstein CORE Center
🇺🇸Chicago, Illinois, United States
Chatham County Health Department
🇺🇸Savannah, Georgia, United States
The Office of Dr. Paul A. Benson, DO
🇺🇸Berkley, Michigan, United States
Kansas University Internal Medicine Midtown Clinic
🇺🇸Wichita, Kansas, United States
Cotton-O'Neil Clinic
🇺🇸Topeka, Kansas, United States
Private Practice
🇺🇸Keego Harbor, Michigan, United States
Partnership Health Center
🇺🇸Missoula, Montana, United States
New York Methodist Hospital
🇺🇸Brooklyn, New York, United States
Metro Health Care
🇺🇸Greenbelt, Maryland, United States
Chase Brexton Health Services Inc
🇺🇸Baltimore, Maryland, United States
Sidney Hillman Family Health Center
🇺🇸New York, New York, United States
NYU School of Medicine
🇺🇸New York, New York, United States
MSU Adult Medicine, 10
🇺🇸Lansing, Michigan, United States
Tufts - New England Medical Center
🇺🇸Boston, Massachusetts, United States
Private Practice (Dr. Mark Scheperle)
🇺🇸St. Louis, Missouri, United States
Chiu-Bin Hsiao, MD
🇺🇸Buffalo, New York, United States
South Jersey Infectious Disease
🇺🇸Somers Point, New Jersey, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Center for Infectious Diseaes
🇺🇸Hackensack, New Jersey, United States
Astor Medical Group, LLP
🇺🇸New York, New York, United States
St. John hospital and Medical Center
🇺🇸Grosse Pointe Woods, Michigan, United States
North Shore University Hospital, Department of Infectious Disease
🇺🇸Manhasset, New York, United States
Upstate Infectious Disease Associates
🇺🇸Albany, New York, United States
University Hospital
🇺🇸Newark, New Jersey, United States
Woodhull Medical Center
🇺🇸Brooklyn, New York, United States
NYM Medical Pavilion
🇺🇸Brooklyn, New York, United States
James I Jones Jr, MD
🇺🇸New York, New York, United States
Bellevue Hospital
🇺🇸New York, New York, United States
Diagnostic Clinic of Longview, PA
🇺🇸Longview, Texas, United States
Dr. James Bromley
🇺🇸San Antonio, Texas, United States
Dr. Steven Fine
🇺🇸Rochester, New York, United States
South Dayton Acute Care Consultants Inc.
🇺🇸Dayton, Ohio, United States
Metro Health Systems
🇺🇸Cleveland, Ohio, United States
Jordon Glaser, MD
🇺🇸Stanton Island, New York, United States
Rosedale Infectious Diseases
🇺🇸Huntersville, North Carolina, United States
The Research & Education Group
🇺🇸Portland, Oregon, United States
RPS Infectious Diseases
🇺🇸West Reading, Pennsylvania, United States
Philadelphia FIGHT
🇺🇸Philadelphia, Pennsylvania, United States
Thomas Street Clinic
🇺🇸Houston, Texas, United States
The University of Texas Health Sciences Center at Houston
🇺🇸Houston, Texas, United States
The Miriam Hospital
🇺🇸Providence, Rhode Island, United States
The Office of Dr. Nicholaos C. Bellos, MD
🇺🇸Dallas, Texas, United States
The Office of Dr. Susan M. Diamond, MD.
🇺🇸Dallas, Texas, United States
Kelly, Allan Rowman MD
🇺🇸Fort Worth, Texas, United States
Hampton Roads Medical Specialists
🇺🇸Hampton, Virginia, United States
Albion Street Centre
🇦🇺Surry Hills, New South Wales, Australia
Clinical Research Unit, Infectious Diseases
🇦🇺Melbourne, Victoria, Australia
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
Fundacion Huesped, Departamento de Investigacion Clinica
🇦🇷Buenos Aires, Argentina
Northside Clinic
🇦🇺North Fitzroy, Victoria, Australia
Sozialmedizinisches Zentrum Baumgartner Hoehe / 2. Interne Lungenabteilung
🇦🇹Wien, Austria
Melbourne Sexual Health Centre
🇦🇺Carlton, Victoria, Australia
Landeskrankenhaus Graz West / Abteilung fuer Innere Medizin 1
🇦🇹Graz, Austria
Cliniques Universitaires Saint-Luc, Maladies Infectieuses
🇧🇪Bruxelles, Belgium
Universitair Ziekenhuis Gent, Inwendige Geneeskunde
🇧🇪Gent, Belgium
Universitair Ziekenhuis Gasthuisberg, Inwendige Geneeskunde
🇧🇪Leuven, Belgium
Clinique médicale l'Actuel
🇨🇦Montreal, Quebec, Canada
CHUM Hôtel-Dieu
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Charleroi, Médecine Interne
🇧🇪Charleroi, Belgium
CHU Sart-Tilman, Medecine Interne
🇧🇪Liège, Belgium
Allgemeines Krankenhaus Wien
🇦🇹A-1090, Austria
Hôpital Erasme, Médecine Interne
🇧🇪Bruxelles, Belgium
Academisch Ziekenhuis VUB
🇧🇪Jette, Belgium
Hôpital Saint Jacques
🇫🇷Besancon, France
Hopital Saint Antoine
🇫🇷Paris, Cedex 12, France
Projet L.O.R.I.
🇨🇦Montreal, Quebec, Canada
Hôpital Saint-andré
🇫🇷Bordeaux Cedex, France
Praxisgemeinschaft Bieniek & Cordes
🇩🇪Berlin, Germany
Centre Hospitalier Universitaire de Caen
🇫🇷Caen, Cedex, France
Hopital Pellegrin - Service des Maladies Infectieuses et Medecine Interne
🇫🇷Bordeaux, France
Universitaetsklinikum Carl Gustav Carus, Klinik und Poliklinik fuer Dermatologie
🇩🇪Dresden, Germany
Fundación para el Desarrollo de la Lucha contra el SIDA
🇨🇷Barrio Aranjuez, San Jose, Costa Rica
Greek Red Cross Hospital
🇬🇷Athens, Attiki, Greece
University Hospital of Patras
🇬🇷Patras, Greece
Gemeinschaftspraxis Dres. Rump und Usadel
🇩🇪Freiburg, Germany
Hopital de l'Hotel-Dieu, Service d'Hepato-Gastroenterologie
🇫🇷Lyon Cedex 02, France
Instituto Dominicano de Estudios Virologicos
🇩🇴Santo Domingo, Dominican Republic
Department of Medicine, St. John's Medical College Hospital
🇮🇳Bangalore, Karnataka, India
Hopital Sainte Marguerite
🇫🇷Marseille, Cedex 09, France
Hopital Avicenne
🇫🇷Bobigny Cedex, France
CHU Michallon
🇫🇷Grenoble Cedex 09, France
Hopital Gui de Chauliac
🇫🇷Montpellier, France
CHU de Nantes - Hopital Hotel Dieu
🇫🇷Nantes, France
Hopital de l Archet 1
🇫🇷Nice Cedex 3, 06, France
Hopital Gabriel Montpied
🇫🇷Clermont Ferrand, France
Hopital La Source
🇫🇷La Source, France
Hopital de Bicêtre
🇫🇷Le Kremlin Bicêtre, France
Centre Hospitalier Cochin Saint Vincent de Paul
🇫🇷Paris CEDEX 14, France
CHU de Tourcoing
🇫🇷Tourcoing, France
Hôpital de Purpan
🇫🇷Toulouse, France
Unita' Operativa Malattie Infettive
🇮🇹Bologna, Italy
Istituto di Malattie Infettive e Tropicali
🇮🇹Brescia, Italy
Unita' Operativa di Malattie Infettive
🇮🇹Venezia, Italy
Universitaetsklinikum Koeln, Klinik I fuer Innere Medizin,
🇩🇪Koeln, Germany
YR Gaitonde Centre for AIDS Research and Education (YRG CARE)
🇮🇳Chennai, Tamil Nadu, India
Universitaetsklinikum Essen, HIV-Ambulanz, Hautklinik
🇩🇪Essen, Germany
Medizinische Hochschule Hannover, Klinische Immunologie, Zentrum Innere Medizin
🇩🇪Hannover, Germany
Dipartimento di Scienze Cliniche, Divisione Clinicizzata Malattie Infettive
🇮🇹Milano, Italy
General Hospital of Athens G. Gennimatas
🇬🇷Athens, Greece
AHEPA Hospital
🇬🇷Thessaloniki, Greece
Presidio Ospedaliero SS Annunziata
🇮🇹Chieti Scalo, Italy
Evagelismos Hospital
🇬🇷Athens, Attiki, Greece
Andreas Sygros Hospital
🇬🇷Athens, Greece
Regional General Hospital Tzaneio
🇬🇷Piraeus, Greece
Universita' degli Studi di Bari, Clinica Malattie Infettive, Policlinico
🇮🇹Bari, Italy
SOD Malattie Infettive, La Piastra dei Servizi
🇮🇹Firenze, Italy
Fondazione Centro San Raffaele del Monte Tabor
🇮🇹Milano, Italy
IRCCS Lazzaro Spallanzani Istituto Nazionale per le Malattie Infettive
🇮🇹Roma, Italy
Centro Hospitalar de Lisboa - Zona Central - Hospital Santo António Capuchos
🇵🇹Lisboa, Portugal
Hospital São João
🇵🇹Porto, Portugal
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Hospital Universitario de Canarias
🇪🇸La Laguna, Santa Cruz de Tenerife, Spain
HOPE Clinical Research
🇵🇷San Juan, Puerto Rico
Spitalul de Boli Infectioase si Tropicale Victor Babes
🇷🇴Bucharest, Romania
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
Complejo Hospitalario Xeral-Cies
🇪🇸Vigo, Pontevedra, Spain
Hospital General de Granollers
🇪🇸Granollers, Barcelona, Spain
Fund. de Gest. Sanitaria de L' Hospital de La Sta. Creu I Sant Pau
🇪🇸Barcelona, Spain
North Manchester General Hospital
🇬🇧Crumpsall, Manchester, United Kingdom
Hospital 12 de Octubre
🇪🇸Madrid, Spain
Universitätsspital Zürich
🇨🇭Zürich, Switzerland
Hospital Costa Del Sol
🇪🇸Malaga, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Complejo Hospitalario Carlos Haya
🇪🇸Malaga, Spain
Complejo Hospitalario Nuestra Señora de Valme
🇪🇸Sevilla, Spain
Imperial College
🇬🇧London, United Kingdom
University of South Florida
🇺🇸Tampa, Florida, United States
Hospital Universitario La Fe
🇪🇸Valencia, Spain
Hospital Virgen Del Rocio
🇪🇸Sevilla, Spain
Hospital Universitario Virgen de La Macarena
🇪🇸Sevilla, Spain
Hospital Clinico Universitario
🇪🇸Valencia, Spain
University of Oklahoma - Schusterman Clinic
🇺🇸Tulsa, Oklahoma, United States
AIDS Medical Centre
🇦🇺Brisbane, Queensland, Australia
Holdsworth House Medical Practice
🇦🇺Darlinghurst, New South Wales, Australia
Westmead Hospital
🇦🇺Wentworthville, New South Wales, Australia
Beth Israel Medical Center
🇺🇸New York, New York, United States
NYHQ
🇺🇸Flushing, New York, United States
Ricky Hsu
🇺🇸New York, New York, United States
Sharon Lewin MD and Michael Rendel MD
🇺🇸New York, New York, United States
Lenox Ave Clinic
🇺🇸New York, New York, United States
Harlem Medical Associates
🇺🇸New York, New York, United States
Mount Sinai Medical Center
🇺🇸New York, New York, United States
Mount Sinai School of Medicine
🇺🇸New York, New York, United States
University of Sout Florida
🇺🇸Tampa, Florida, United States
Midtown Medical Center
🇺🇸Tampa, Florida, United States
Associates in Infectious Diseases
🇺🇸Port St. Lucie, Florida, United States
Roger Trinh
🇺🇸Chicago, Illinois, United States
Private Practice (Dr. Gregory Kuldanek)
🇺🇸Grand Rapids, Michigan, United States
Kaiser Permanente-Northwest Region, Immune Deficiency Clinic
🇺🇸Portland, Oregon, United States
Tarrant County Infectious Disease Associates
🇺🇸Ft. Worth, Texas, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Barbara Cassie
🇺🇸Lynchburg, Virginia, United States
The Office of Dr. Gordon E. Crofoot, MD.
🇺🇸Houston, Texas, United States
DCOL Center for Clinical Research
🇺🇸Longview, Texas, United States
Clinical Alliance for Research & Education - Infectious Diseases
🇺🇸Annandale, Virginia, United States
Infectious Diseases
🇺🇸Arlington, Virginia, United States
The Vancouver Clinic, Inc., P.S.
🇺🇸Vancouver, Washington, United States
Emerald City Medical Arts
🇺🇸Seattle, Washington, United States
Group Health Cooperative
🇺🇸Seattle, Washington, United States
The Office of Dr. Daniel R. Coulston, MD
🇺🇸Spokane, Washington, United States
Universita'Cattolica del Sacro Cuore Policlinico Gemelli
🇮🇹Roma, Italy
Azienda Ospedaliera San Giovanni Addolorata
🇮🇹Roma, Italy
Canadian Immunodeficiency Research Collaborative
🇨🇦Toronto, Ontario, Canada
Fernando Garcia, MD
🇺🇸Harlingen, Texas, United States
Atlanta VA Medical Center
🇺🇸Decatur, Georgia, United States
CAMC Memorial Hospital
🇺🇸Charleston, West Virginia, United States
Fort Sutter Medical Complex
🇺🇸Sacramento, California, United States
Sutter Institute for Medical Research
🇺🇸Sacramento, California, United States
Sutter Medical Group
🇺🇸Sacramento, California, United States
Orlando Immunology Center
🇺🇸Orlando, Florida, United States
Infectious Diseases of Central Florida
🇺🇸Orlando, Florida, United States
Nemechek Health Renewal
🇺🇸Kansas City, Missouri, United States
Investigational Drug Services
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Bronx Lebanon Hospital Center
🇺🇸Bronx, New York, United States
Allmed Medical and Rehabilitaion of NY
🇺🇸Bronx, New York, United States
Crossover Ministry
🇺🇸Richmond, Virginia, United States
Community Research Initiative of New England
🇺🇸Springfield, Massachusetts, United States
St Stephens Research Ltd
🇬🇧London, United Kingdom
Department of Sexual Health
🇬🇧London, United Kingdom
Department of Medicine Queen Elizabeth Hospital
🇭🇰Kowloon, Hong Kong