Effects of Muscle Strengthening and Fatigue on Activities in Cortex and Muscle

Not Applicable

Completed

• Conditions: Healthy Adults
• Interventions: Other: Cross education

• Registration Number: NCT06333756
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction.

Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity

Detailed Description

Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown.

The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.

Study Timeline

• Study Start: 2021-05-01
• Primary Completion: 2022-04-30
• Study Completion: 2022-08-01
• Status Verified: 2022-12
• Study First Submitted: 2024-03-20
• Study First Submitted QC: 2024-03-20
• Last Update Submitted: 2024-03-20
• Study First Posted: 2024-03-27
• Last Update Posted: 2024-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Healthy adults who are 20-40 years old

Exclusion Criteria

1. Upper extremity (UE) pain or discomfort
2. Medical condition that substantially influenced their UE strength
3. Experience of UE surgery
4. Paresthesia in UE
5. Open wound on UE

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cross education training group	Cross education	Cross education on elbow flexor

Primary Outcome Measures

Name	Time	Method
Corticomuscular coherence	Measured immediately after cross education training	Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction
Corticocortical coherence	Measured immediately after cross education training	Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction
Maximal voluntary contraction	Measured immediately after cross education training	The ability to generate maximal voluntary elbow flexor force

Trial Locations

Locations (1)

National Yang-Ming University; 🇨🇳 Taipei, Taiwan