Comparison of the efficacy and safety of administering of Tranexamic acid and Dexmedetomidine and Nitroglycerine in preventing bleeding and the quality of ?the surgical site during septorhinoplasty under general anesthesia
Phase 2
Recruiting
- Conditions
- septorhinoplasty.Nasal polyp
- Registration Number
- IRCT20141209020258N121
- Lead Sponsor
- Arak University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
18 to 60 years
Suitable control for blood pressure
No addiction to opioids
Body mass index less than 35
Exclusion Criteria
Not having satisfaction to perform surgery
Sensitivity to the drugs studied
Need for prescribing low blood pressure drugs, in addition to those used in each group
Coagulation disorders
History of cardiovascular disease
Pregnancy
Chronic pulmonary disease(Asthma)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean arterial blood pressure. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Digital sphygmomanometer.;Heart rate. Timepoint: Every 15 minutes to end of surgery. Method of measurement: ECG.;Percent of oxygen saturation. Timepoint: Every 15 minutes to end of surgery. Method of measurement: Pulse oximetry.;Recovery time. Timepoint: Recovery time. Method of measurement: Chronometer.;Duration of surgery. Timepoint: End of surgery. Method of measurement: chronometer.;Amount of Propofol consumed. Timepoint: End of surgery. Method of measurement: Milligram of drug in 24 hours.;Amount of bleeding. Timepoint: During surgery. Method of measurement: Observation.
- Secondary Outcome Measures
Name Time Method