Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders

Not Applicable

Recruiting

• Conditions: Schizophrenia; Bipolar Disorder
• Interventions: Other: fMRI; Other: EEG

• Registration Number: NCT02765880
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering simple visual stimuli and/or personal events.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-04-15
• Study First Submitted QC: 2016-05-06
• Study First Posted: 2016-05-09
• Study Start: 2017-03-16
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-16
• Last Update Posted: 2024-08-19
• Primary Completion: 2025-09
• Study Completion: 2025-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 161

Inclusion Criteria

• Age between 18 and 60 years
• Affiliation to a social security insurance
• Written consent given
• Only for patient : DSM criteria for schizophrenia or bipolar disorder

Exclusion Criteria

• Addiction problem
• Invalidating visual sensory problems
• Neurological history
• Pregnancy or breastfeeding
• Legal safeguard
• Participation in another clinical trial
• Contraindication to MRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patient with bipolar disorder	fMRI	-
Healthy volunteer	fMRI	-
Healthy volunteer	EEG	-
Patients with schizophrenia	EEG	-
Patients with schizophrenia	fMRI	-
Patient with bipolar disorder	EEG	-

Primary Outcome Measures

Name	Time	Method
Abnormalities in connectivity during order judgement tasks will be taken as seeds to check whether they account for abnormalities in connectivity at rest, by means of mathematic modelization	After study completion (2 years)

Secondary Outcome Measures

Name	Time	Method
Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during rest.	After study completion (2 years)
- Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during time ordering.	After study completion (2 years)
Comparison of patients with schizophrenia vs. bipolar disorder	During fMRI and EEG sessions

Trial Locations

Locations (1)

Service de psychiatrie; 🇫🇷 Strasbourg, France