Discover In-Hospital Cardiac Arrest

Completed

• Conditions: Cardiac Arrest

• Registration Number: NCT06207201
• Lead Sponsor: Montefiore Medical Center

Brief Summary

The Discover In-Hospital Cardiac Arrest (IHCA) study is a multicenter, prospective observational study aimed at better understanding variations in practice for the post-in-hospital cardiac arrest patient.

Detailed Description

There is considerable debate among experts concerning many components of intra- and post-arrest care. This study aims to increase the evidence base of these components, particularly temperature control, and prognostication in post-in-hospital cardiac arrest patients. In addition to providing insights regarding immediate and long-term post-arrest care, data collected will also be useful in studying variations in cardiopulmonary resuscitation practices.

This project is endorsed by the Society of Critical Care Medicine's (SCCM) Discovery, the Critical Care Research Network.

Study Timeline

• Study Start: 2023-10-16
• Study First Submitted: 2023-12-20
• Study First Submitted QC: 2024-01-11
• Study First Posted: 2024-01-16
• Primary Completion: 2024-05-30
• Study Completion: 2024-06-30
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-12
• Last Update Posted: 2024-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1050

Inclusion Criteria

• Adult (≥18 years old) patients
• Patients with a cardiac arrest (a lack of palpable pulse or perfusing cardiac activity) while admitted to the hospital
• Patients admitted to a ward (telemetry or non-telemetry) or an intensive care unit, or are admitted but still in the emergency department waiting for a hospital bed
• Patients who achieved return of spontaneous circulation (ROSC defined as >20 minutes of sustained spontaneous circulation) OR initiated on extracorporeal membrane oxygenation (eCPR) with chest compressions ongoing
• Patients survived for 6 hours after ROSC

Exclusion Criteria

• Cardiac arrest in non-inpatients (e.g. outpatients, visitors)
• Patients whose cardiopulmonary resuscitation (CPR) starts outside of the hospital
• Non-index arrests (arrests that are not the patient's first arrest during the hospital admission; this also excludes patients who were initially admitted for an out-of-hospital cardiac arrest)
• Patients suffering IHCA in the operating room (OR) or post anesthesia care unit (PACU)
• Patients with cardiac arrest after arriving to an emergency department (ED) but prior to being evaluated and admitted to the hospital
• Cardiac arrests lasting <2 minutes (i.e. chest compressions performed <2 minutes)
• Cardiac arrests where the patient is transitioned to comfort focused care within 6 hours of return of spontaneous circulation (ROSC)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fever Incidence	Up to 96-hours post cardiac arrest	The incidence of fever from ROSC until 96 hours after ROSC among patients who remain comatose
Multimodal Prognostication	Up to 60 days post cardiac arrest	The use of at least two approaches for prognostication prior to withdrawal of care from ROSC until hospital discharge
Early Withdrawal of Care	Up to 72-hours post cardiac arrest	The withdrawal of care from ROSC until 72-hour after ROSC

Trial Locations

Locations (1)

Montefiore Medical Center; 🇺🇸 Bronx, New York, United States