Discover In-Hospital Cardiac Arrest: A Prospective Multicenter Study of Post-In-Hospital Cardiac Arrest Management Practices
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,050
- 试验地点
- 1
- 主要终点
- Fever Incidence
研究概览
简要总结
The Discover In-Hospital Cardiac Arrest (IHCA) study is a multicenter, prospective observational study aimed at better understanding variations in practice for the post-in-hospital cardiac arrest patient.
详细描述
There is considerable debate among experts concerning many components of intra- and post-arrest care. This study aims to increase the evidence base of these components, particularly temperature control, and prognostication in post-in-hospital cardiac arrest patients. In addition to providing insights regarding immediate and long-term post-arrest care, data collected will also be useful in studying variations in cardiopulmonary resuscitation practices.
This project is endorsed by the Society of Critical Care Medicine's (SCCM) Discovery, the Critical Care Research Network.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult (≥18 years old) patients
- •Patients with a cardiac arrest (a lack of palpable pulse or perfusing cardiac activity) while admitted to the hospital
- •Patients admitted to a ward (telemetry or non-telemetry) or an intensive care unit, or are admitted but still in the emergency department waiting for a hospital bed
- •Patients who achieved return of spontaneous circulation (ROSC defined as >20 minutes of sustained spontaneous circulation) OR initiated on extracorporeal membrane oxygenation (eCPR) with chest compressions ongoing
- •Patients survived for 6 hours after ROSC
排除标准
- •Cardiac arrest in non-inpatients (e.g. outpatients, visitors)
- •Patients whose cardiopulmonary resuscitation (CPR) starts outside of the hospital
- •Non-index arrests (arrests that are not the patient's first arrest during the hospital admission; this also excludes patients who were initially admitted for an out-of-hospital cardiac arrest)
- •Patients suffering IHCA in the operating room (OR) or post anesthesia care unit (PACU)
- •Patients with cardiac arrest after arriving to an emergency department (ED) but prior to being evaluated and admitted to the hospital
- •Cardiac arrests lasting <2 minutes (i.e. chest compressions performed <2 minutes)
- •Cardiac arrests where the patient is transitioned to comfort focused care within 6 hours of return of spontaneous circulation (ROSC)
结局指标
主要结局
Fever Incidence
时间窗: Up to 96-hours post cardiac arrest
The incidence of fever from ROSC until 96 hours after ROSC among patients who remain comatose
Multimodal Prognostication
时间窗: Up to 60 days post cardiac arrest
The use of at least two approaches for prognostication prior to withdrawal of care from ROSC until hospital discharge
Early Withdrawal of Care
时间窗: Up to 72-hours post cardiac arrest
The withdrawal of care from ROSC until 72-hour after ROSC
次要结局
未报告次要终点