Assessment of oleoylethanolamide supplementattion in the prevention and treatment of obesity

Not Applicable

• Conditions: obesity.; Obesity due to excess calories; E66.0

• Registration Number: IRCT201607132017N30
• Lead Sponsor: Vice-Chancellor for Research of Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 October 2019

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

healthy obese subjects in both genders (males and females)
Ages between 18 to 59 years
body mass index 30-40 kg/m2

Exclusion Criteria

having kidney problems, liver failure, heart failure, rheumatic diseases and gastrointestinal diseases
smoking
Breastfeeding and pregnancy and menopause
Taking probiotic and prebiotic supplements, vitamin, minerals, omega-3 and weight-reducing drugs and antibiotics during past one month

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gene expression of PPAR-a. Timepoint: before and after supplementation. Method of measurement: Real time-PCR.;Inflammatory biomarkers (IL-6? TNF-a ? hs-CRP). Timepoint: before and after supplemenation. Method of measurement: IL-6 and TNF-a using ELISA, hs-CRP using spectrometry method.;The abundance of Akkermansia muciniphila bacteria in stool samples. Timepoint: before and after supplemenation. Method of measurement: colony count.;Total antioxidant capacity. Timepoint: before and after supplemenation. Method of measurement: using ELISA method.;Lipid profiles and fasting blood glucose. Timepoint: before and after supplementation. Method of measurement: Using ELISA method.;Dietary intake. Timepoint: before and after supplemenation. Method of measurement: Three days food record questionnaire.

Secondary Outcome Measures

Name	Time	Method
Anthropometric measurements. Timepoint: at baseline and at the end of intervention. Method of measurement: Using a stadiometertape and tape in accordance with the standards.;Appetite status. Timepoint: at baseline and at the end of study. Method of measurement: Visual Analouge Scale questionnaire.