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Predictive Factors of Response to Somatostatin Analogues in Acromegalic Patients With Persistent Disease Following Surgery

Completed
Conditions
Acromegaly
Registration Number
NCT00500227
Lead Sponsor
Ipsen
Brief Summary

The objective of this study is to evaluate, in acromegalic patients with disease persistence after surgery who are treated with somatostatin analogues, the histopathological, clinical, morphological and biochemical factors which are predictive of hormonal control.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
55
Inclusion Criteria
  • Acromegalic patients with persistent disease (growth hormone ≥ 1ng/ml following oral glucose tolerance test and/or insulin like growth factor 1 above the normal range for sex and age) 3 to 6 months after transsphenoidal or transfrontal surgery
Exclusion Criteria
  • Patients not contributing enough material for a tumour histopathological study
  • Patients who have received radiation therapy or will receive it during the observational study period
  • Patients who are being treated, or in whom treatment is anticipated, with either a dopaminergic agonist or a growth hormone receptor antagonist
  • Patients with a history of hypersensitivity to somatostatin analogues

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (30)

Hospital "Juan Canalejo"

🇪🇸

A Coruña, Spain

Hospital General Universitari d'Alacant

🇪🇸

Alicante, Spain

Hospital de Cruces

🇪🇸

Barakaldo, Spain

Hospital de la Santa Creu i Sant Pau

🇪🇸

Barcelona, Spain

Hospital General de la Vall d´Hebron

🇪🇸

Barcelona, Spain

Hospital Clínic i Provincial de Barcelona

🇪🇸

Barcelona, Spain

Hospital "Mútua de Terrassa"

🇪🇸

Barcelona, Spain

Hospital Prínceps d'Espanya

🇪🇸

Barcelona, Spain

Hospital Universitario de Getafe

🇪🇸

Getafe, Spain

Complejo Hospitalario de León. Hospital Virgen Blanca.

🇪🇸

Leon, Spain

Scroll for more (20 remaining)
Hospital "Juan Canalejo"
🇪🇸A Coruña, Spain

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