Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Recruitment
研究概览
简要总结
The overall goal of this study is to evaluate the feasibility of conducting a randomized controlled trial comparing a standardized dialysis strategy versus usual care (dialysis prescription ordered by each patient's primary nephrologist) in patients with AKI-receiving dialysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Received ≥2 sessions of any dialysis modality for presumed AKI
- •Plans for continued intermittent hemodialysis or sustained low efficiency dialysis treatments
排除标准
- •Receipt of dialysis for ≥90 days
- •Known baseline estimated glomerular filtration rate (eGFR) <15mL/min/1.73m2
- •Strong clinical suspicion of urinary tract obstruction, rapidly progressive glomerulonephritis (RPGN), vasculitis, thrombotic microangiopathy (TMA), myeloma related cast nephropathy, or acute interstitial nephritis (AIN) as the underlying cause of AKI
- •Receipt of any dialysis prior to the current admission within the past 2 months
- •Kidney transplant within the past 12 months
研究组 & 干预措施
Standardized Dialysis and Structured Discontinuation (S2D2)
Prescription to minimize dialysis-induced ischemia and standardize dialysis discontinuation
干预措施: Standardized Dialysis and Structured Discontinuation (S2D2) (Other)
Usual Care
Dialysis prescription ordered by their primary nephrologist/intensivist.
干预措施: Usual Care (Other)
结局指标
主要结局
Recruitment
时间窗: 2 years
Recruitment of the target population to the RCT
Fidelity
时间窗: 2 years
At least 80% of randomized participants remain in the trial and on the allocated study treatment
次要结局
- Dialysis-Free Days(6-months)
- Hypotensive Event on Dialysis(6-months)
研究者
Samuel Silver
Dr. Samuel A Silver
Queen's University