Post-transplant Cancer Incidence and Survival in Patients With or Without Pre-transplant Cancer

Completed

• Conditions: Neoplasms; Kidney Failure

• Registration Number: NCT02491580
• Lead Sponsor: Uppsala University

Brief Summary

Patients with previous malignancies have increasingly been accepted for renal transplantation. However, post-transplant malignancy risk and survival rates of these patients are unknown. Our aim was to assess if previous malignancies pose an unnecessarily high risk of post-transplant malignant tumours and if the organs as a resource are too limited for investment in this patient group.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Study First Submitted: 2015-06-30
• Status Verified: 2015-07
• Study First Submitted QC: 2015-07-02
• Last Update Submitted: 2015-07-02
• Study First Posted: 2015-07-08
• Last Update Posted: 2015-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2370

Inclusion Criteria

• Kidney transplanted patients from January 1982 through December 2013 with or without a pre transplant cancer.

Exclusion Criteria

• Simultaneous kidney+pancreas transplantation.
• Islet cell transplanted patients
• Undiagnosed malignancies at the time of transplantation
• Death within a week after transplantation
• First transplantation at another hospital

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of post-transplant cancer	Up to 33 years starting in January 1982.

Secondary Outcome Measures

Name	Time	Method
Patient survival	Up to 33 years starting in January 1982.
Cancer-induced mortality	Up to 33 years starting in January 1982.

Trial Locations

Locations (1)

Uppsala University, Department of Surgical Sciences, Section of Transplantation Surgery; 🇸🇪 Uppsala, Sweden