Investigating the Role of Yoga in Alleviating Chromosomal Translocations in Security Guards of Chandigarh Police Who Are Responsible for the Safety of VIPs
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 203
- 试验地点
- 2
- 主要终点
- Prevalence of t(14;18) translocations using Nested PCR method
研究概览
简要总结
The goal of this Non-Randomized Control Trial is to evaluate the prevalence of chromosomal translocations in occupationally stressed subjects and the molecular impact of yoga on such translocations and DNA damage response and repair in security guards of Chandigarh Police. The main questions it aims to answer are:
Does yoga has any role in alleviating chromosomal translocations in healthy but occupationally stressed subjects? Does practice of yoga has any impact on molecular markers related to DNA damage response and repair before and after Yoga intervention in highly stressed individuals? Researchers will compare Control Group and Yoga group before and after Yoga intervention.
Participants will be divided into two groups Control Group and Yoga Group. Yoga Group will be given yoga intervention for 3 months, 5 days a week and for 65 minutes in a day. Control Group will follow their daily routine without following the intervention. Before and after the intervention, blood samples will be collected from the participants of both groups and analysed for chromosomal translocations and DDRR markers.
详细描述
Definition of the problem: Evaluate the molecular impact of yoga on DNA damage response and repair on security guards of Chandigarh Police
Objectives:
- Analysis of molecular markers related to DNA damage response and repair before and after the practice of yoga on Chandigarh Police
- To examine the molecular mechanism by which yoga may modulate DNA damage response and repair.
Recruitment of individuals: Department of Police, Chandigarh has agreed to help the investigators on this aspect. Policemen working for Chandigarh Police will be chosen based on the inclusion and exclusion criteria.
Subjects: Those security guards (age: >20 and <60) who are willing to consent to participate in this study will be screened for moderate and higher stress on Cohen's PSS, according to inclusion criteria and randomly divided between Intervention (Yoga Group) and Control Group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals scoring more than 15 points on Cohen's scale. Once these subjects' consent to enrol, each one of them will be coded to maintain anonymity.
排除标准
- •Individuals with complications in co-morbid conditions like Diabetes, Cirrhosis, etc.
- •Individuals of age less than 25 or more than 60 years.
- •Individuals who do not consent to be a part of this study.
- •Individuals who fail to comply with the yoga protocol in Intervention Group.
结局指标
主要结局
Prevalence of t(14;18) translocations using Nested PCR method
时间窗: 3 months
Both control and yoga group will be assessed for prevalence of chromosomal translocations t(14;18) before and after yoga (IAYT) intervention. This prevalence will be measured as relative band intensity for each individual and will be compared for before and after IAYT intervention, and also for between the groups after intervention.
次要结局
- Cohen's Perceived Stress Scale(3 months)
- Six Letter Cancellation Test (SLCT)(3 months)
- Trail Making Test (TMT)(3 months)
- Relative Telomere Length using Real-Time PCR(3 months)
- Serum cortisol level using enzyme-linked immunosorbent assay(3 months)
研究者
Sheetal Sharma
Principal Investigator
Post Graduate Institute of Medical Education and Research, Chandigarh