Comparison of the efficacy of Metformin and Simvastatin in patients with polycystic ovarian syndrome(PCOS) in Intra Cytoplasmic Sperm Injection(ICSI )cycles.

Phase 2

• Conditions: Infertility.; Female infertility associated with anovulation

• Registration Number: IRCT201202138994N1
• Lead Sponsor: Ahwaz Jundishapur University of Medical Sciences,Vice Chancellor for Research and Technology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

PCOS, age 20-35, previous history of infertility for at least 1year.
Exclusion criteria: tubal infertility, anatomical factors & malformations, male infertility factors, endometriosis, receiving metformin , clomiphene or letrozol, IUI in last 3 months, underline disease such as renal, pulmonary, diabetes mellitus, anti phospholipid syndrome and hypertrigelyceridemia and receiving anti hyperlipidemia drugs

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pregnancy rate. Timepoint: 16 weeks. Method of measurement: Serum B-HCG.

Secondary Outcome Measures

Name	Time	Method
Body mass index. Timepoint: Before and 2 month after intervention. Method of measurement: BMI index.;TG,Chol(HDL,LDL),FSH,LH,Total Testesteron,GGT with 75 g glucose. Timepoint: Before and 2 month after intervention. Method of measurement: Lab data analize.;Staging of hirsutism. Timepoint: 2 month after intervention. Method of measurement: standard scaling score system.;Ovarian hyperstimulation syndrome. Timepoint: After puncture. Method of measurement: Physical exam and sonography.;Number of oocyte in mitosis 2. Timepoint: After puncture. Method of measurement: Lab data analize.;Number of fetus in grade A. Timepoint: After sperm injection. Method of measurement: Lab data analize.;Cases of ectopic pregnancy. Timepoint: 6 weeks after fetus transfer. Method of measurement: Sonography.;Cases of abortion. Timepoint: 6 weeks after fetus transfer. Method of measurement: physical exam and sonography.