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临床试验/NCT07258277
NCT07258277尚未招募不适用

Comparative Study Between Adductor Canal Block With IPACK (Infiltration Between the Popliteal Artery and Capsule of the Knee) Versus Genicular Nerves Block With IPACK for Post-operative Analgesia in Knee Arthroscopy

Minia University1 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2025年12月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
72
试验地点
1
主要终点
first analgesic request

研究概览

简要总结

In our study, we will find out the efficacy of those peripheral nerve blocks on postoperative pain in knee arthroscopy.

The aim is to evaluate the efficacy of combined ultrasound-guided IPACK with adductor canal nerve block versus ultrasound-guided IPACK with genicular nerves block on postoperative pain in knee arthroscopy.

详细描述

Effective perioperative pain treatment has been documented to facilitate accelerated rehabilitation and recuperation, hence providing improved functional outcomes among individuals following knee surgeries. As a result, there has been a need to create multimodal analgesic regimens that include the usage of both regional anesthetic and systemic analgesics (Society, 2012).

Management of pain for knee surgery has been challenging, where various methods like epidural, peripheral nerve block (PNB), Local Infiltration Analgesia (LIA), intravenous (IV) analgesics like opioids, non-steroidal anti-inflammatory drugs (NSAIDs) and intra-articular (IA) injections, have been used (Tian et al., 2020).

In knee surgeries, the most difficult factor to control is pain, but early movement following surgery can be facilitated by motor-sparing regional anesthetic blocks and ultrasound-guided nerve blocks (Leung et al., 2018).

Perioperative multimodal analgesic strategies, consisting of "motor-sparing" regional anesthetic techniques combined with systemic nonopioid medications that target various pain pathways, have been developed to mitigate this risk; they confer improved pain scores and patient satisfaction, reduced opioid consumption and opiate-related adverse effects, early postoperative ambulation, shortened hospital stay, and fewer surgical complications (Kandarian et al., 2019).

The adductor canal block (ACB) is a regional anesthesia technique used to provide analgesia to the anterior and medial areas of the thigh and the knee (El-Boghdadly et al., 2021).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
20 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •ASA l & ll
  • •planned to undergo elective unilateral knee surgeries under spinal anesthesia
  • •age between 20 to 70 years old

排除标准

  • •Patient refusal
  • •Neurological deficiencies prior to surgery
  • •Severe Cardiovascular, renal and hepatic comorbidities
  • •Hematological disorders and abnormal coagulation parameters
  • •Psychiatric illnesses and opioid addiction
  • •Allergies to any of the medications will be utilized in the study

研究组 & 干预措施

IA (IPACK with adductor cannal block)

Active Comparator

receive ultrasound-guided IPACK block in supine position with externally rotated leg and flexed knee, 15 ml of 0.25% plain bupivacaine then another 15 ml of 0.25% plain bupivacaine at the mid-thigh for the ACB.

干预措施: IPACK with adductor canal block (Other)

IG (IPACK with genicular nerves block)

Active Comparator

receive ultrasound-guided IPACK block in supine position with externally rotated leg and flexed knee, 15 ml of 0.25% plain bupivacaine then at the anterior surface of the knee 16 ml of 0.25% plain bupivacaine divided on the 4 genicular nerves (superior medial, superior lateral, inferior medial and inferior lateral).

干预措施: IPACK with Genicular nerves block (Other)

C (Spinal block)

Active Comparator

won't receive any nerve block, only spinal anesthesia.

- Then spinal anesthesia will be given to all patients in the three groups, 3 ml (15 mg) 0.5% hyperbaric bupivacaine will be administered intrathecal at level of L3-4 or L4-5 interspace.

干预措施: Spinal Block (Other)

结局指标

主要结局

first analgesic request

时间窗: within 24 hours

the first time the patient will ask analgesia postoperative

次要结局

  • Changes in Visual Analogue Score(To be measured immediately postoperative, 2h later, 4h, 6h, 8h, 12h, 18h, 24h)
  • Total analgesic requirement(within 24 hours)
  • Time Up and Go Test (TUG)(postoperative: 6h, 12h, 18h and 24h.)

研究者

发起方
Minia University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Gehad Fathy Mohamed Sadek

Lecturer of Anesthesiology and ICU

Minia University

研究点 (1)

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