Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

Phase 3

Recruiting

• Conditions: Schizophrenia
• Interventions: Other: Placebo; Drug: Brilaroxazine

• Registration Number: NCT05184335
• Lead Sponsor: Reviva Pharmaceuticals

Brief Summary

This study is to evaluate the effect and safety of Brilaroxazine in patients with acute schizophrenia compared to the placebo short and long-term. Brilaroxazine will be given at fixed doses of 15 mg or 50 mg once daily over 4 weeks, then in the long-term flexible doses 15-50mg daily over a period of 52 weeks.

Detailed Description

This is a randomized, double-blind (DB), placebo-controlled, multicenter study to assess the efficacy and safety of RP5063 (brilaroxazine) at fixed doses of 15 mg or 50 mg, administered once daily (OD) for 28 days (28 days DB treatment) in subjects with an acute exacerbation of schizophrenia. The study further will assess the safety of RP5063 (brilaroxazine) at flexible doses of either 15, 30 or 50 mg administered OD in an Open Label (OL) treatment over a period of 52 weeks (52-week OL treatment part), in subjects with stable schizophrenia. The OL treatment will have 2 populations of stable schizophrenia: DB rollover and de novo subjects.

The study comprises 2 parts: a 28-day DB treatment, followed by 52 weeks OL treatment.

The total duration of the study is 56 weeks (28 days/4 weeks DB treatment and 52-weeks OL treatment).

Study Timeline

• Study First Submitted: 2021-11-29
• Study First Submitted QC: 2022-01-07
• Study First Posted: 2022-01-11
• Study Start: 2022-01-24
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-16
• Last Update Posted: 2024-12-19
• Primary Completion: 2025-02
• Study Completion: 2025-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 690

Inclusion Criteria

1. Subject is male or female, aged 18 to 65 years
2. Subject reads, understands, and signs an Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved current ICF prior to performing any of the Screening procedures
3. Diagnosis schizophrenia

Exclusion Criteria

1. Has a history of treatment resistance exhibited by any of the following:

   1. No or minimal response to at least 2 periods of treatment lasting 28 days or longer, with antipsychotic agents at the maximally tolerated dose.
   2. Lifetime history of clozapine use
   3. History of electroconvulsive therapy (ECT) for treatment of schizophrenia within the past 5 years.

2. Is treatment-naïve for schizophrenia.

3. Primary current diagnosis other than schizophrenia or a comorbid diagnosis that is primarily responsible for the current symptoms and functional impairment.

4. Has a current diagnosis of a psychotic disorder other than schizophrenia or a behavioral disturbance thought to be due to substance abuse disorder.

5. Meets criteria for moderate-to-severe substance use disorder within past 6 months prior to Screening (excluding those related to caffeine or nicotine).

6. Has a history of the following: (a) traumatic brain injury causing ongoing cognitive difficulties, Alzheimer's disease, or another form of dementia, or any chronic organic disease of the central nervous system (CNS) (b) intellectual disability of a severity that would impact ability to participate in the study.

7. Subject has a current primary DSM-5 diagnosis other than schizophrenia, including schizoaffective disorder, major depressive disorder, post-traumatic stress disorder, obsessive-compulsive disorder, manic episode, hypomania, panic disorder, delirium, amnestic or other cognitive disorders. Also, subjects with borderline, paranoid, histrionic, schizotypal, schizoid, or antisocial personality disorder.

8. On antipsychotic within the Screening Period (minimum 3 days prior to Baseline and throughout the study).

9. Within 28 days prior to Baseline: monoamine oxidase (MAO) inhibitors, CNS stimulants, potent CYP3A4/5 enzyme-inducing drugs including but not limited to rifampin and carbamazepine and strong CYP3A4/5 inhibitors like ketoconazole, itraconazole, clarithromycin, etc. (see Appendix 20.1 for prohibited medications).

10. Antipsychotic depot medication within 5 half-lives prior to Baseline.

11. Positive Urine Drug Screen for drugs of abuse, including amphetamines, barbiturates, cocaine, ecstasy, phencyclidine or opiates meeting criteria of moderate-to-severe DSM-5 substance use disorder.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	administered OD for 28 days.
RP5063 (brilaroxazine) 50 mg once daily	Brilaroxazine	administered OD for 28 days, then flexibly 15-50mg over a period of 52 weeks
RP5063 15 mg once daily	Brilaroxazine	administered OD for 28 days then flexibly 15-50mg over a period of 52 weeks.

Primary Outcome Measures

Name	Time	Method
Double Blind Safety and Efficacy of Brilaroxazine (RP5063)	28 days	decrease in Positive and Negative Symptoms Assessment total score compared to placebo from Baseline to Day 28.
Open label Safety and Efficacy of Brilaroxazine (RP5063)	52 weeks	(brilaroxazine) tablets (at flexible doses of 15 mg or 30 mg 0r 50mg OD) in an treatment part over a period of 52 weeks in stable schizophrenia subjects. The endpoints would be incidence of Treatment-Emergent Adverse Events \[Safety and Tolerability\])

Trial Locations

Locations (1)

Reviva site; 🇺🇸 Richardson, Texas, United States