The role of free fatty acids in the glucose-lowering effects of thiazolidinediones.
Completed
- Conditions
- Patients with DM II.
- Registration Number
- NL-OMON25285
- Lead Sponsor
- Eli Lilly
- Brief Summary
J Clin Endocrinol Metab. 2007 Jan;92(1):166-71. Epub 2006 Oct 24.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 13
Inclusion Criteria
1. Obese patients with Diabetes Mellitus type II (DM II);
2. BMI > 25 kg/m2;
Exclusion Criteria
1. Use of insulin;
2. Use of fibrates;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Basal glucose production and plasma FFA<br>peripheral insulin sensitivity<br>insulin-mediated suppression of FFA (=insulin sensitivity of adipose tissue).
- Secondary Outcome Measures
Name Time Method Changes in concentrations of ceramide and glycosphingolipids in skeletal muscle.