Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia

Completed

• Conditions: Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Childhood Acute Promyelocytic Leukemia (M3); Adult Acute Myeloid Leukemia; Adult Acute Promyelocytic Leukemia (M3)
• Interventions: Other: laboratory biomarker analysis

• Registration Number: NCT01146223
• Lead Sponsor: Children's Oncology Group

Brief Summary

This research study is studying biomarkers in patients with acute promyelocytic leukemia. Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and about biomarkers related to cancer.

Detailed Description

OBSERVATIONAL STUDY MODEL: Case-only TIME PERSPECTIVE: Retrospective BIOSPECIMEN RETENTION: Samples With DNA BIOSCPECIMEN DESCRIPTION: Bone marrow STUDY POPULATION DESCRIPTION: Primary Care Clinic SAMPLING METHOD: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To measure WT1 and VEGF-1 expression in patients with acute promyelocytic leukemia.

OUTLINE: This is a multicenter study.

Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2010-06-16
• Study First Submitted QC: 2010-06-16
• Study First Posted: 2010-06-17
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-06
• Last Update Posted: 2015-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Diagnosis of acute promyelocytic leukemia [t(15;17) translocation]
• Not specified
• Not specified

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Basic science (correlative studies)	laboratory biomarker analysis	Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.

Primary Outcome Measures

Name	Time	Method
WT1 and VEGF-1 expression	Baseline

Trial Locations

Locations (1)

Children's Oncology Group; 🇺🇸 Monrovia, California, United States