The PREPARE-MVR Study: PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Right Heart Failure
- Sponsor
- Semmelweis University Heart and Vascular Center
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- right ventricular failure
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The PREPARE-MVR (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) Study aims to evaluate those preoperative factors which can predict the early postoperative right ventricular failure or determine the functional shift seen in right ventricular function after mitral valve replacement/repair. The PREPARE-MVR study focuses mainly on echocardiographic (both conventional and advanced) parameters and includes right heart catheterization intraoperatively and in the early postoperative period as gold standard method.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients admitted for mitral valve replacement/repair
- •severe mitral valve insufficiency
Exclusion Criteria
- •preoperative right ventricular dysfunction
- •cardiac surgery in medical history
- •infective endocarditis
- •primary cardiomyopathies
- •congenital heart disease
- •decreased left ventricular ejection fraction
- •pulmonary embolism in medical history
- •severe chronic obstructive pulmonary disease
- •primary pulmonary hypertension
- •any malignancy affecting right heart
Outcomes
Primary Outcomes
right ventricular failure
Time Frame: From date of operation until the date of first documented right ventricular failure assessed up to 6 months
Early postoperative right ventricular failure is defined as right ventricular stroke work index \<300 mmHg/mL/m2 measured by right heart catheterization. Late right ventricular failure is defined as \>10% decrease in right ventricular ejection fraction compared to preoperative value measured by 3D echocardiography.