Population Burden of STI and Implication for Intervention in Hong Kong

Completed

• Conditions: STI
• Interventions: Other: self-sampling kits for STI testing in laboratory

• Registration Number: NCT04793841
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

This is a 5-year cross-disciplinary sexually transmitted infection (STI) project involving a) territory-wide and community-based studies (survey and specimen collection); b) simulation of STI transmission dynamics and comparison of STI intervention strategies through mathematical modelling and cost-effectiveness analysis. The aim of this project is to assess the burden and the transmission dynamics of STIs in the general population and men who have sex with men (MSM) in Hong Kong. Around 1300 sexually experienced adults and 900 MSM would be recruited, 100 participants would be invited for individual in-depth interviews. Main outcome measures include STI history and service preference, effectiveness as measured by the proportion of new STI infections (chlamydia, gonorrhoea and human papillomavirus infections) averted above base-case scenario, and incremental cost-effectiveness ratio.

Detailed Description

After completion of baseline questionnaire, the participants are invitied for STI self-sampling. If agree, a package of self-sampling kits, instructions, and packaging materials for return post would be delivered to their selected collection points. The second round of self-sampling would be offered at least one year from the first round of self-sampled specimens collected.

Study Timeline

• Study First Submitted: 2021-02-01
• Study First Submitted QC: 2021-03-09
• Study First Posted: 2021-03-11
• Study Start: 2021-05-13
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-14
• Last Update Posted: 2025-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1977

Inclusion Criteria

• aged 18 or above
• ever having sex
• normally living in Hong Kong
• can communicate in English or Chinese

Exclusion Criteria

• failed to provide consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
men who have sex with men	self-sampling kits for STI testing in laboratory	men who have sex with men aged 18 or above and normally living in Hong Kong
General population	self-sampling kits for STI testing in laboratory	sexually experienced adults (aged 18 or above) of the randomly selected household

Primary Outcome Measures

Name	Time	Method
self-reported STI diagnosis in questionnaire	up to 2 years	number of STI diagnosis
effectiveness of STI intervention strategies	10 years	incremental cost-effectiveness ratio

Secondary Outcome Measures

Name	Time	Method
willingness to pay for STI testing reported in questionnaire	12 months	willingness to pay (HKD)
STI symptom reported in questionnaire	12 months	types of symptom presentations
prevalence of STI estimated through laboratory testing	12 months	prevalence of chlamydia trachomatis, Neisseria gonorrhoeae and human papillomavirus infections from self-collected samples

Trial Locations

Locations (1)

The Chinese University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong, China, Hong Kong