How Menopause Affects Lipid Metabolism in the Visceral Fat Depots
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Insulin sensitivity
研究概览
简要总结
The purpose of the study is to describe the molecular mechanisms related to an increased visceral fat mass and changed T-cell homeostasis. the project is expected to add new knowledge to the field of metabolic diseases after menopause and increase the focus of how lipid affects the development of metabolic disease in relation to the menopausal transition.
详细描述
The study is a cross sectional study including 60 women between 45 and 55 years of age. Investigators aim to include 20 premenopausal women, 20 postmenopausal women and 20 postmenopausal women taking hormone treatment (HT). All the women are going through gynecological surgery for benign reasons. During the operation investigators will take a visceral fat biopsy from the omentum.
maximally 1 month before- or after the operation the subject will meet at the lab for further testing, including:
- Health examination
- Blood samples
- OGTT
- DXA scan
- VO2 max testing
- MRI of the abdomen
- hyperinsulinemic euglycemic clamp
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 45 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •45-55 years old
- •for HT treated women (HT more than 1 year)
排除标准
- •Infections during the last month
- •chronic disease
- •claustrophobia
- •Alcoholic intake > 14 servings
- •hysterectomy before menopause
- •oophorectomized
- •early menopause (before 40 yrs)
- •BMI > 30
结局指标
主要结局
Insulin sensitivity
时间窗: 4 weeks
measured through a hyperinsulinemic euglycemic clamp (Outcome: glucose infusion rate)
次要结局
未报告次要终点
研究者
Anders Rasmussen Rinnov
MD, phd-student
Rigshospitalet, Denmark