NCT01089244Unknown不适用
Molecular Correlates and Clinical Significance of Positron Emission Tomography With FET-PET in Combination With Perfusion-weighted Magnetic Resonance Imaging (PWI) in Patients With Low Grade Gliomas
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Overall survival
研究概览
简要总结
The aim of the study is to compare the two imaging modalities perfusion weighted MR-imaging and FET-PET in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within a homogeneously appearing tumor. Additionally, therapeutic effects should be assessed during a time period of two years.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •neuroradiologically suspected low grade glioma (Astrocytoma WHOI-II, Oligodendroglioma WHO II, Oligoastrocytoma WHO II)
- •histological verification will be obtained either by microsurgery or by stereotactic biopsy
- •patients older than 18 years
- •Karnofsky Performance Score >=70
- •pregnant or nursing female patients will not be included in this study
排除标准
- •patients in whom informed consent cannot be obtained due to organic brain syndrome or insufficient language skills
- •patients who cannot lie quiet for a time period of app. two hours during the FET-PEt scan
- •medical history of a metastatic brain disease
- •patients in whom an MRI scan cannot be performed due to claustrophobia metallic protheses or pacemakers etc.
结局指标
主要结局
Overall survival
时间窗: 24 months
次要结局
- Progression Free survival(24 months)
研究者
Bogdana Suchorska
PI
Ludwig-Maximilians - University of Munich
研究点 (2)
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