BioEvocs - Testing the 'poo sniffer' in children and young people with eosinophilic esophagitis
- Conditions
- Eosinophilic esophagitisDigestive System
- Registration Number
- ISRCTN10653410
- Lead Sponsor
- Alder Hey Children's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 120
For EoE:
Children attending endoscopy or clinic for known EoE or to investigate symptoms indicating flare-up of disease symptoms contacting the department, or patients found to have EoE who are awaiting treatment.
For controls:
Control patients identified in gastroenterology or ophthalmology outpatient clinics
1. Patients unable to provide a faecal sample
2. Patients and parents unable to give informed consent
3. Previous colonic resection
4. Patients on an elemental diet unrelated to EoE
5. Current or treatment with systemic antibiotics in the previous 4 weeks
6. Patients with known chronic gastro-intestinal infection or chronic diarrhoea
7. Patients with confirmed and clinically significant irritable bowel syndrome
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patterns of volatile organic compounds associated with active EoE, measured using gas chromatography-mass spectrometry at baseline and 3 months
- Secondary Outcome Measures
Name Time Method 1. Patterns of volatile organic compounds treated with medical (oral viscous budesonide) or dietetic (elimination diet) treatment, measured using gas chromatography-mass spectrometry at baseline and 3 months<br>2. Patient disease activity measured using Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) score at baseline and 3 months<br>3. Nutritional status and atopic background measured using Environmental questionnaire at baseline<br>4. Microbiome selected analysis and CGR (Centre for Genomic Research) sequencing of fecal sample at baseline and 3 months