Comparison of Acute Tart Cherry Supplement Formulation and Dose on Inflammation and Oxidative Capacity
- Conditions
- InflammationOxidative Stress
- Interventions
- Dietary Supplement: tart cherryDietary Supplement: placebo
- Registration Number
- NCT04497077
- Lead Sponsor
- Ohio University
- Brief Summary
A comparison of acute tart cherry formations (juice vs. powdered) and doses (single vs. twice daily) on inflammation and oxidative capacity.
- Detailed Description
Participants will be randomly allocated to a group: one tart cherry capsule daily, two tart cherry capsules daily, one 8oz. bottle of tart cherry juice daily, two 8oz. bottles of tart cherry juice taken 8 hours apart, one placebo pill, and one 8oz. bottle of placebo. Participants will arrive to the lab at 8 am after an overnight fast of 10 hours. They will provide a blood sample and then ingest their study treatment. Participants will stay in the lab for a further 2 hours for additional blood draws then return to the lab in 6 hours for another blood draw. At this time if they are in a twice daily group they will receive their second treatment for the day. All participants will come back to the lab 24 hours later where they will give a blood sample and receive their next treatment. If they are in the twice daily group they will be provided with their next dose and given instructions to consume it in 8 hours. Participants will arrive 24 hours later for a final blood draw with no supplementation.
Blood samples will be measured pre-ingestion, 1 hour, 2 hours, 8 hours, 24 hours and 48 hours post-ingestion. Samples will be analyzed for plasma oxygen radical absorbance capacity (ORAC), uric acid (UA), and C-reactive protein (CRP).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
- free of cardiovascular, metabolic and inflammatory conditions
- non-smokers
- no known allergy to cherries or cherry juice
- not be taking food supplements (turmeric/curcumin, cherry products, greens, etc.).
- quit smoking less than one year ago.
- currently being treated for arthritis or an inflammatory condition.
- currently being treated for uncontrolled cardiovascular disease, high blood pressure, diabetes, fibromyalgia, or irritable bowel syndrome.
- pregnant.
- regularly consume cherries or are allergic to cherries or dairy.
- currently use anti-inflammatory medications,
- have used corticosteroids in the last two months.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description double dose tart cherry capsule tart cherry double dose tart cherry capsule double dose tart cherry juice tart cherry double dose tart cherry juice single dose tart cherry juice tart cherry single dose tart cherry juice single placebo capsule placebo single placebo capsule single placebo juice placebo single placebo juice single dose tart cherry capsule tart cherry single dose tart cherry capsule
- Primary Outcome Measures
Name Time Method Change in c-reactive protein 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion c-reactive protein (mg/L) measured via assay
Change in oxidative capacity 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion oxygen radical absorbance capacity (uM Trolox equivalents) measured via assay
Change in uric acid 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion uric acid (mg/dL) measured via assay
- Secondary Outcome Measures
Name Time Method