Adjunctive Methods In Treatment Of Odontogenic Keratocyst

Not Applicable

Completed

• Conditions: Keratocysts of the Jaw

• Registration Number: NCT06820229
• Lead Sponsor: Tanta University

Brief Summary

The purpose of this study was to compare both clinically and radiographically the effect of using 5- fluorouracil cream (5-FU) versus modified carnoy's solution (MCS) as adjunctive methods in treatment of odontogenic keratocyst (OKC).

Patients and methods :This is an interventional, comparative study that was carried on 20 patients with mandibular odontogenic keratocyst and were divided randomly into two equal groups, Group I: included 10 patients in whom OKCs were treated with enucleation and peripheral ostectomy followed by application of 5-FU cream. Group II: included 10 patients in whom OKCs were treated with enucleation and peripheral ostectomy followed by application of MCS. All patients were followed up for 9 months postoperatively.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-02
• Primary Completion: 2024-10-02
• Study Completion: 2025-01-04
• Status Verified: 2025-02
• Study First Submitted: 2025-02-06
• Study First Submitted QC: 2025-02-06
• Last Update Submitted: 2025-02-10
• Study First Posted: 2025-02-11
• Last Update Posted: 2025-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• patients with biopsy proved odontogenic keratocyst

Exclusion Criteria

• relevant systemic diseases which might affect healing process.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
degree of pain pain	6 month	degree of pain pain is measured on a visual analogue scale (VAS) started from 0 which represent (no pain at all) and end by 10 which represent (most severe pain)
swelling	6 month	Swelling is assessed using a vertical and horizontal references with a tape on four reference points; outer canthus of the eye, angle of the mandible, tragus, and outer corner of the mouth

Secondary Outcome Measures

Name	Time	Method
Quantitative computed tomography (CT)	12 month	Quantitative interpretation of values derived from Hounsfield units with a suitable calibration procedure is the modality of choice to determine the local bone mineral density during the follow up periods

Trial Locations

Locations (1)

Tanta University; 🇪🇬 Tanta, Gharbia, Egypt