The influence of oral valproate on propofol metabolism
Not Applicable
- Conditions
- Patients with oral valproate
- Registration Number
- JPRN-UMIN000008711
- Lead Sponsor
- Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Dental Anesthsiology and Special Care Dentistry
- Brief Summary
There were no significant differences in the propofol level at 5, 10, 15, and 20 min or the free propofol level at 5 min after the intravenous administration of propofol. However, the minimum BIS was significantly lower and the time until the BIS exceeded 60 was significantly longer in the poly-VPA group. In the multivariate regression analysis, belonging to the poly-VPA group was found to be independently associated with the minimum BIS value and the time until the BIS exceeded 60.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 33
Inclusion Criteria
Not provided
Exclusion Criteria
Patients without consent of the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change of BIS index during anesthesia induction, the serum concentration of propofol after injection and the change of blood pressure and heart rate during anesthesia
- Secondary Outcome Measures
Name Time Method