Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery

Not yet recruiting

• Conditions: Ischemic Heart Disease
• Interventions: Drug: Milrinone Injection

• Registration Number: NCT04153383
• Lead Sponsor: Konkuk University Medical Center

Brief Summary

The purpose of this study is to analyze the changes in cardiac performance before and after milrinone administration in order to find out whether milrinone improves LV performance in patients undergoing coronary artery bypass surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-11-04
• Study First Submitted QC: 2019-11-04
• Study First Posted: 2019-11-06
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-26
• Last Update Posted: 2023-09-28
• Study Start: 2024-09
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• patient agree and provide written informed consent.
• patient undergoing elective coronary artery bypass graft surgery
• preoperative LV EF>50% (TTE)

Exclusion Criteria

• preoperative cardiac dysrhythmia
• preoperative IABP
• use of other inotropic agents

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
TMAD	Milrinone Injection	Tissue motion annular displacement (TMAD) of tricuspid valve annulus transesophageal echocardiography

Primary Outcome Measures

Name	Time	Method
TMAD of ticuspid annulus during early relaxation	15 mini after milrinone administration

Secondary Outcome Measures

Name	Time	Method
left ventricular ejection fraction	15 min after milline administration
global longitudinal strain of the right ventricle	15 mini after milrinone administration
global longitudinal strain of the left ventricle	15 min after milline administration