Perioperative Evaluation of Immuno-inflammatory Parameters
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Combined Inflammatory and Immunologic Defect
- Sponsor
- Université Catholique de Louvain
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Immune parameters (immunocytes phenotype)
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
This study consists of evaluations, using blood tests, various immune, inflammatory and coagulation parameters in the perioperative settings (different substudies), without changing anything to what is expected.
This will allow us to clarify the possible impact of surgery and analgesia on perioperative activation of these pathways.
Detailed Description
A significant number of published data can be concluded that surgery and anesthetic and analgesic techniques have an impact on immunity and inflammation. However, none of these studies have been performed with modern techniques, much more reliable evaluation of immune activity, such as the assessment of monocytic degranulation by flow cytometry. It is therefore important to document immune activity using these new techniques, our patients, perioperative. This will be analyzed, so observational, the potential impact of different therapeutic interventions the patient receives. This study consists of evaluations, using blood tests, various immune, inflammatory and coagulation parameters in the perioperative settings (different substudies), without changing anything to what is expected. This will allow us to clarify the possible impact of surgery and analgesia on perioperative activation of these pathways.
Investigators
Forget Patrice
Principal Investigator
Université Catholique de Louvain
Eligibility Criteria
Inclusion Criteria
- •Surgical patients (and controls)
Exclusion Criteria
- •Immune disorders
Outcomes
Primary Outcomes
Immune parameters (immunocytes phenotype)
Time Frame: baseline up to 8 days (return to baseline)
Function tests and surface markers
Secondary Outcomes
- Long term outcome(5 years)
- Coagulation parameters (like platelet function) (substudy)(perioperative period (up to 3 days))
- Inflammatory markers (cytokines) (substudy)(baseline up to 8 days (return to baseline))