MR-Evaluation of Renal Function-After-Pancreas-transplantation

• Conditions: Diabetes; Renal Failure; Pancreas Transplantation

• Registration Number: NCT01537445
• Lead Sponsor: Uppsala University

Brief Summary

The purpose of this study is to evaluate the beneficial effect of pancreas transplantation for long term kidney function in patients undergoing single-pancreas transplantation.

Detailed Description

Renal failure in patients who have performed a pancreas transplantation is a hazard for the outcome for these patients. The beneficial effect of pancreas transplantation for renal function is not clear. It is of major importance to early find patients who develops a decrease in renal function and start treatment early and closely monitor these patients in order to avoid further deteriorating renal function. In order to achieve this, there is a need for a easy, fast and sensitive method to evaluate renal function. In this study the investigators plan to use the non-invasive MR to evaluate changes in renal function.

Study Timeline

• Status Verified: 2012-02
• Study Start: 2012-02
• Study First Submitted: 2012-02-13
• Study First Submitted QC: 2012-02-22
• Last Update Submitted: 2012-02-22
• Study First Posted: 2012-02-23
• Last Update Posted: 2012-02-23
• Primary Completion: 2015-02
• Study Completion: 2015-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients with diabetes mellitus
• Patients undergoing a pancreas transplantation

Exclusion Criteria

• Patients undergoing a pancreas transplantation and a renal transplantation at the same time.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Kidney function	Within 3 years	Improvements in kidney function (GFR) and proteinuria after pancreas transplantation.

Secondary Outcome Measures

Name	Time	Method
Kidney hemodynamics and oxygenation	Within 3 years	Improvements in renal blood flow and kidney tissue oxygenation after pancreas transplantation.

Trial Locations

Locations (1)

University Hospital; 🇸🇪 Uppsala, Sweden