Antibiotic Resistant Helicobacter Pylori in Rajavithi Hospital
- Conditions
- Dyspepsia
- Interventions
- Procedure: gastroscopic examination
- Registration Number
- NCT00285688
- Lead Sponsor
- Rajavithi Hospital
- Brief Summary
Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide. The gold standard for Helicobacter pylori eradication is composed of Proton-pump inhibitor/Ranitidine bismuth citrate + Amoxycillin + Metronidazole /Clarithromycin. In Thailand, clarithromycin resistant strains increased and led to treatment failure. Data on file at Rajavithi Hospital showed that metronidazole resistant H. pylori was about 50% and Clarithromycin resistant strains accounted for 8%. This molecular genetic study will be performed in patients presenting with dyspepsia, who had an indication for gastroscopic examination, to explore the incidence of antibiotic resistant Helicobacter pylori in Rajavithi Hospital, Thailand.
- Detailed Description
Genetic and Biomolecular factors determining clarithromycin resistance will be characterized.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- male or female with dyspepsia
- age > 15 years
- fulfil indication for gastroscopic examination
- able to give informed consent
- contraindication for gastroscopic examination and biopsy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 2 gastroscopic examination Gastroscope positive for H. pylori and not resistant to clarithromycin 1 gastroscopic examination Gastroscope positive for H. pylori and resistant to clarithromycin
- Primary Outcome Measures
Name Time Method Incidence of H. pylori Clarithromycin resistance gene one year
- Secondary Outcome Measures
Name Time Method Characteristic of H. pylori clarithromycin resistant gene mutation one year
Trial Locations
- Locations (1)
Rajavithi Hospital
🇹🇭Ratchathewi, Bangkok, Thailand