Comparison Between Midpoint Transverse Process to Pleura (MTP) Block vs Erector Spinae Plane (ESP) Block for Acute Herpes Zoster (HZ) Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Incidence of post-herpatic neuralgia
研究概览
简要总结
The aim of this study is to compare the analgesic efficacy and safety of ultrasound-guided midpoint transverse process block versus ultrasound-guided erector spinae plane block in patients suffering from thoracic herpes zoster pain.
详细描述
Herpes zoster is caused by reactivation of latent varicella-zoster virus in dorsal root or cranial nerve ganglia and commonly presents with unilateral dermatomal rash associated with severe neuropathic pain.
The erector spinae plane block is an ultrasound-guided interfascial plane block in which local anesthetic is deposited deep to the erector spinae muscle adjacent to the transverse process, allowing multidermatomal spread and thoracic analgesia. Recent studies support its efficacy in herpes zoster pain management.
The midpoint transverse process to pleura block is a paravertebral-by-proxy technique where local anesthetic is injected midway between the posterior border of the transverse process and pleura. It may provide thoracic segmental analgesia with lower pleural puncture risk and easier sonoanatomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 21-60 years.
- •Both sexes.
- •American Society of Anesthesiologists (ASA) physical status I-II.
- •Acute thoracic herpes zoster within 30 days of rash onset.
- •Moderate to severe pain [numeric rating scale (NRS)≥4].
排除标准
- •Refusal to participate.
- •Coagulopathy or anticoagulant therapy.
- •Infection at puncture site.
- •Allergy to study drugs.
- •Severe psychiatric illness or inability to assess pain.
- •Previous thoracic surgery deformity.
- •Uncontrolled Diabetic patient.
- •Chronic diseases as renal, hepatic, malignancy.
- •Patients with chronic disease need analgesia.
- •Patients are coming for more than 3 months (after healing of rash).
结局指标
主要结局
Incidence of post-herpatic neuralgia
时间窗: After 12 weeks of block
Incidence of post-herpatic neuralgia will be recorded after 12 weeks of block
次要结局
- Blood pressure(24 hours postoperatively)
- Heart rate(24 hours postoperatively)
- Oxygen saturation(24 hours postoperatively)
- Time to first rescue analgesia(24 hours postoperatively)
- Total rescue analgesics consumption(24 hours postoperatively)
- Degree of pain(12 weeks postoperatively)
- Total anti-convulsant drugs(12 weeks postoperatively)
- Assessment of sleep quality(12 weeks postoperatively)
- Incidence of complications(24 hours postoperatively)
研究者
Mohamed Ahmed Kazamel
Resident of Anesthesia, Intensive Care and Pain Management, Tanta University, Egypt.
Tanta University