Effects of Topical Neomycin on Skin Graft Outcomes in Rural Bangladesh: a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 142
- 试验地点
- 1
- 主要终点
- Post-operative infection rate
研究概览
简要总结
The goal of this study is to see if putting antibiotic ointment on a skin graft when the surgery is being done helps prevent the skin graft from getting infected after the operation. The study is looking at all skin grafts done in a rural Bangladesh hospital.
The main questions it aims to answer are:
Does the antibiotic lower the number of infections that happen? Does the antibiotic make the overall outcome of the skin graft better? Do patients who get the antibiotic need fewer extra surgeries?
Researchers will compare the outcomes from patients who had skin grafts before the hospital started applying antibiotic ointment to the outcomes of patients after the hospital began applying antibiotic ointment.
Participants who have already had their skin graft treatment completed will have their medical records reviewed by researchers. The outcomes of their treatment will be written down.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient undergoing a split-thickness skin graft at the hospital where research is conducted
排除标准
- •Missing or incomplete medical record
研究组 & 干预措施
Neomycin
Patients who had skin graft procedure after the topical antibiotic protocol was initiated. Patients had topical neomycin applied at the time of their surgeries.
干预措施: Neomycin (Drug)
结局指标
主要结局
Post-operative infection rate
时间窗: Measured if present at any time during the patient's initial post-operative hospitalization, which averaged 20 days, from time of operation until time of discharge.
Whether patients had post-operative infection during their hospitalization, classified as "yes" or "no" as defined by any of the following being present: "post-operative infection" diagnosis written in the patient's medical record, change or increase in antibiotic therapy post-operatively, or the presence of pus documented at the skin graft site.
次要结局
- Skin graft take(Measured at the time of discharge from the patient's initial post-operative hospitalization, which averaged 20 days.)
- Need for operative re-intervention(From the time of operation until the end of the study period (up to three years for the earliest skin graft patients).)
- Length of stay(Measured at the time of discharge from the patient's initial post-operative hospitalization, which averaged 20 days.)
- Allergic reaction(Measured if present at any time during the patient's initial post-operative hospitalization, which averaged 20 days, from time of operation until time of discharge.)
研究者
Jonathan Egle
General Surgeon, Deputy Medical Director
LAMB Project