Retinal Therapy Guided by 3D OCT Image Analysis

Completed

• Conditions: Age-Related Macular Degeneration; Choroidal Neovascularization

• Registration Number: NCT02308215
• Lead Sponsor: Michael Abramoff

Brief Summary

The main purpose is to find a better way to predict the timing of treatments given to patients with Wet Age-related macular degeneration using image analysis.

Detailed Description

The study focuses on making better use of advanced three-dimensional imaging and analysis to allow physicians to know when a treatment is being effective and thus not overuse it. The study will examine how 3-D optical coherence tomography and related image analysis can be used to assess changes in the macula and retina of patients' eyes. These changes can reveal how well a person is responding to anti-VEGF treatment and thus help doctors provide proper treatment timing and care.

Study Timeline

• Study Start: 2010-07
• Study First Submitted: 2014-11-13
• Study First Submitted QC: 2014-12-01
• Study First Posted: 2014-12-04
• Primary Completion: 2018-07-05
• Study Completion: 2018-07-05
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-28
• Last Update Posted: 2019-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• fundoscopically confirmed AMD and patient eligible for treatment with anti-VEGF

Exclusion Criteria

• Patients with a CNV due to other causes (OHS, trauma)
• eyes that have been previously treated for CNV

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure central retinal layer thickness in µms.	one year
Measure amount of fluid in the retina in µms.	one year

Trial Locations

Locations (1)

University of Iowa Hospitals Dept of Ophthalmology; 🇺🇸 Iowa City, Iowa, United States