Hypoglycemia and Autonomic Nervous System Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 4
- 主要终点
- Change in Baroreflex Sensitivity
研究概览
简要总结
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Euglycemic hyperinsulinemic clamp
participant undergoes a euglycemic hyperinsulinemic clamp
干预措施: Euglycemic hyperinsulinemic clamp (Other)
Hypoglycemic hyperinsulinemic clamp
participant undergoes a hypoglycemic hyperinsulinemic clamp
干预措施: Hypoglycemic hyperinsulinemic clamp (Other)
结局指标
主要结局
Change in Baroreflex Sensitivity
时间窗: 16 hours after euglycemic and hypoglycemic clamps as compared to baseline
The change in baroreflex sensitivity (milliseconds/mm Hg) is calculated as baroreflex sensitivity (milliseconds/mm Hg) on day 3 \[assessed 16 hours after the clamp\] minus baroreflex sensitivity (milliseconds/mm Hg) on day 1 \[baseline assessment on the day prior to the clamp\]). Change in baroreflex sensitivity in euglycemic clamp arm is compared to change in baroreflex sensitivity in hypoglycemic arm.
次要结局
- Muscle Sympathetic Nerve Activity(16 hours after euglycemic and hypoglycemic clamps)
- Catecholamine Response to Lower-body Negative Pressure(16 hours after euglycemic and hypoglycemic clamps)
研究者
Gail Adler
Associate Professor of Medicine
Brigham and Women's Hospital