Hypoglycemia and Autonomic Nervous System Function
- Conditions
- Hypoglycemia
- Registration Number
- NCT01816893
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in Baroreflex Sensitivity 16 hours after euglycemic and hypoglycemic clamps as compared to baseline The change in baroreflex sensitivity (milliseconds/mm Hg) is calculated as baroreflex sensitivity (milliseconds/mm Hg) on day 3 \[assessed 16 hours after the clamp\] minus baroreflex sensitivity (milliseconds/mm Hg) on day 1 \[baseline assessment on the day prior to the clamp\]). Change in baroreflex sensitivity in euglycemic clamp arm is compared to change in baroreflex sensitivity in hypoglycemic arm.
- Secondary Outcome Measures
Name Time Method Muscle Sympathetic Nerve Activity 16 hours after euglycemic and hypoglycemic clamps Muscle sympathetic nerve activity (MSNA), at rest and immediately after nitroprusside, was measured on Day 3 about 16 hours after the euglycemic and hypoglycemic clamps.
Catecholamine Response to Lower-body Negative Pressure 16 hours after euglycemic and hypoglycemic clamps Plasma norepinephrine response to lower body negative pressure (at the minus 40 mm Hg data point) on Day 3 about 16 to 20 hours after completion of the euglycemic or hypoglycemic clamp.
Trial Locations
- Locations (2)
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center🇺🇸Boston, Massachusetts, United States