The Effects of Antioxidant Supplementation on Multiple Endurance Race Performance, Physiology, and Recovery.

Not Applicable

Completed

• Conditions: Oxidative Stress; Muscle Damage; Resistance Training; Body Composition; Muscle Strength
• Interventions: Other: Cross Training Course; Dietary Supplement: Oceanix

• Registration Number: NCT04314596
• Lead Sponsor: Applied Science & Performance Institute

Brief Summary

Thirty active male and female athletes will be recruited for the study. Subjects will be examined at baseline for VO2max performance. Subjects will then be stratified and randomly divided equally (50% - 50%) into an Oceanix (supplemental) or placebo condition such that baseline VO2max match. Once randomization, subjects will be baseline tested for multiple measures of muscle force capacity, muscle soreness, immune function, and endocrine function. Upon completion of baseline testing, subjects will all complete a one-day, cross-training course in Tampa, Florida. The training course is known to be extremely vigorous and causes significant muscle damage. Subjects will then be retested for muscle function at 24, and 48 hours following the course. At 24- and 48-hours subjects will be asked to repeat a simulated time trial race. In this way, we will measure repeated race performance, recovery from intense exercise, muscle damage from exercise, and immune function during multiple races.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-20
• Primary Completion: 2020-02-12
• Study Completion: 2020-02-19
• Status Verified: 2020-03
• Study First Submitted: 2020-03-17
• Study First Submitted QC: 2020-03-18
• Last Update Submitted: 2020-03-18
• Study First Posted: 2020-03-19
• Last Update Posted: 2020-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Males and females age 18 to 45 years old
• At least one year of cross training experience (i.e. 3 days/week)

Exclusion Criteria

• BMI of 30 or more kg/m²
• Any allergies to fish, shellfish, algae, or seaweed are excluded from participation
• Have any cardiovascular, metabolic, or endocrine disease
• Undergone surgery that affects digestion and absorption
• Smoking
• Drink heavily (> 7 and > 14 drinks per week for women and men, respectively)
• Women who are pregnant or planning to be pregnant
• Taking medication to control blood pressure, lipids, and blood glucose
• Have taken or currently taking anabolic-androgenic steroids

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo Group	Cross Training Course	Participants will engage in a one day, whole-body, cross-training course while consuming a visually identical placebo (25mg hydroxypropyl methylcellulose) 30 minutes prior to exercise on training days or with the first meal of the day on non-training days. Participants will then come in 24 and 48 hours post, cross-training course to be tested.
Experimental Group	Cross Training Course	Participants will engage in a one day, whole-body, cross-training course while consuming the treatment condition (Oceanix™) 30 minutes prior to exercise on training days or with the first meal of the day on non-training days. Participants will then come in 24 and 48 hours post, cross-training course to be tested.
Experimental Group	Oceanix	Participants will engage in a one day, whole-body, cross-training course while consuming the treatment condition (Oceanix™) 30 minutes prior to exercise on training days or with the first meal of the day on non-training days. Participants will then come in 24 and 48 hours post, cross-training course to be tested.

Primary Outcome Measures

Name	Time	Method
Changes in Perceived Recovery Status (PRS)	Baseline, 1 Day of Cross-Training Course, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Assessed through a visual analog scale (modified Borg Scale) numbered 0 to 10 with visual descriptors.
Changes in Perceived Soreness Scale	Baseline, 1 Day of Cross-Training Course, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Assessed through a visual analog scale numbered 0 to 10 with visual descriptors.
Changes in Rating of Perceived Exertion (RPE)	Baseline, 1 Day of Cross-Training Course, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Assessed through a visual analog scale numbered 0 to 10 with visual descriptors.
Changes in muscle strength	Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Assessed by isometric mid-thigh pull.
Changes in One(1) Mile Timed Run	Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Experimental outcome assessing how quickly a 1 mile run can be completed.
Changes in muscle power	Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Assessed through ground reaction forces during countermovement and squat jumps on a force plate.

Secondary Outcome Measures

Name	Time	Method
Creatine Kinase	Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Experimental outcome examining creatine kinase in fasted whole blood samples. This is biomarker an indirect measure of muscle damage.
Cortisol	Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course.	Experimental outcome examining the concentration of cortisol in fasted saliva samples.

Trial Locations

Locations (1)

Applied Science & Performance Institute; 🇺🇸 Tampa, Florida, United States