The mesopancreas and pancreatic head carcinoma: from preoperative imaging to histopathological and surgical outcome

Conditions: C25.0
Head of pancreas

Registration Number: DRKS00029558

Lead Sponsor: Abteilung für Allgemein-, Viszeral- und KinderchirurgieUniversitätsklinikum Düsseldorf

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 500

Inclusion Criteria

patients who receive primary surgery
patients with neoadjvuant treatment prior to surgery
CRM Implemented in pathological institute according to LEEPP

Exclusion Criteria

Palliation, abort of operation, no CRM implemented in pathology institute, no preoperative CT (minimum bisphasic)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence rate of mesopancreatic adipose tissue infiltration in a multicentric setting<br>Statistical comparison of the mesopancreatic adipose tissue infiltration status with known oncologically relevant histopathological staging factors: is there a more aggressive tumor biology or an unfavorable tumor topography?<br>Statistical comparison of mesopancreatic adipose tissue infiltration status with the CRM of the dorsal resection margin and with the entire CRM<br>Prediction value of preoperative fat stranding in computed tomography with mesopancreatic adipose tissue infiltration status in primary and neoadjuvantly patients

Secondary Outcome Measures

Name	Time	Method
Incidence rate of mesopancreatic adipose tissue in primary and borderline resectable pancreatic head carcinomas (classification of resectability using the well-known ABC scheme)<br>Prediction value of preoperative fat stranding in computed tomography with the mesopancreatic adipose tissue infiltration status in primary and borderline resectable pancreatic head carcinoma<br>Incidence rate of mesopancreatic adipose tissue infiltration in neoadjuvant and primary surgical patients (matched-pairs analysis: both patient groups (neoadjuvant vs. primary surgical) must have similar resectability criteria).