NCT02056821
Completed
Not Applicable
Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke
ConditionsIschemic Stroke
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ischemic Stroke
- Sponsor
- Henry Ford Health System
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- Change in cerebral blood flow velocities
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.
Investigators
Joseph Miller, MD
Senior Staff
Henry Ford Health System
Eligibility Criteria
Inclusion Criteria
- •Suspected ischemic stroke within 12 hours of symptom onset
- •NIHSS ≥ 4
- •Age 18 to 90 years
Exclusion Criteria
- •Baseline modified Rankin Scale \> 3
- •Pregnancy
- •Intracranial hemorrhage on head CT
- •Mechanical ventilation prior to enrollment
- •Inadequate temporal windows for TCD analysis
Outcomes
Primary Outcomes
Change in cerebral blood flow velocities
Time Frame: initial 24 hours
Cerebral flow velocities determined by bilateral MCA measurements by TCD
Study Sites (1)
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