NCT02056821已完成不适用
Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Change in cerebral blood flow velocities
研究概览
简要总结
This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected ischemic stroke within 12 hours of symptom onset
- •NIHSS ≥ 4
- •Age 18 to 90 years
排除标准
- •Baseline modified Rankin Scale > 3
- •Pregnancy
- •Intracranial hemorrhage on head CT
- •Mechanical ventilation prior to enrollment
- •Inadequate temporal windows for TCD analysis
结局指标
主要结局
Change in cerebral blood flow velocities
时间窗: initial 24 hours
Cerebral flow velocities determined by bilateral MCA measurements by TCD
次要结局
未报告次要终点
研究者
Joseph Miller, MD
Senior Staff
Henry Ford Health System
研究点 (1)
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