Fatigue in patients with primary Sjögren*s syndrome
Completed
- Conditions
- Sjögren's syndrome10003816
- Registration Number
- NL-OMON43326
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 49
Inclusion Criteria
Both patients and control subjects:
> Age: 18-65 years
> Adequate hand function that allows subjects to utilize the force transducer
> Patients: diagnosed with pSS according to AECG and/or ACR-EULAR classification criteria
Exclusion Criteria
Both patients and control subjects:
> Drug or alcohol addicition
> Neurologic condition unrelated to pSS
> Psychiatric disorder
> Other condition influencing fatigue
> Medication influencing fatigue or the immune system
> fMRI related exclusion criteria
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The most important parameters are the maximal FDI muscle force, force decline<br /><br>during the fatiguing task, muscle activation during the fatiguing task,<br /><br>questionnaire scores, and the changes in cortical activation during the<br /><br>fatiguing task (functional MRI data).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Electromyographic activity of the FDI muscle during the motor tasks</p><br>