Intraosseous With Intra-articular Injection of Platelet Rich Plasma Versus Hyaluronic Acid in Treatment of Knee Osteoarthritis
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 86
- 主要终点
- WOMAC scores
研究概览
简要总结
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP), intra-articular injection of PRP and a single application of hyaluronic acid (HA).
详细描述
Methods Eighty-six patients from January 2015 to June 2015 with grade II to grade III knee osteoarthritis according to the Kellgren-Lawrence classification were randomly divided into 3 groups to receive either PRP or HA. Group A received intra-articular injection of PRP 2 ml combination with medial tibial plateau and medial femoral condyle injection of PRP 2 ml (once more 2 weeks later). Group B were treated with 2 ml of PRP intra-articular injection every 14 days for a total of two injections. Group C received intra-articular injection of hyaluronic acid 2 ml every 7 days for five injections. All patients were evaluated by the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) score before the treatment and at 1st, 3rd, 6th, 12th and 18th months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 73 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Unilateral symptomatic knee with pain for at least 1 month or swelling.
- •Radiographic findings of knee degeneration (Kellgren-Lawrence score of II - III).
- •Age 40-73 years.
- •Body mass index (BMI) 18-32.5).
- •Knee stability without a severe trauma history.
排除标准
- •Bilateral knee osteoarthritis indicative of treatment for both knees.
- •Kellgren-Lawrence score greater than III.
- •Age >73 years.
- •Systemic autoimmune rheumatic diseases and blood disorders.
- •Active immunosuppressive or anticoagulant therapy.
- •Intra-articular injection to the knee within the previous 1 year or previous joint infection.
- •use of corticosteroids for 3 weeks before the procedure.
- •use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the 3 weeks before treatment.
研究组 & 干预措施
Intraosseous and intra-articular
injection of PRP 2 ml
干预措施: PRP (Drug)
intra-articular PRP
injection PRP 2 ml
干预措施: PRP (Drug)
Intra-articular injection of HA
injection of HA 2 ml
干预措施: HA (Drug)
结局指标
主要结局
WOMAC scores
时间窗: At the 18th month
The evaluation was performed with WOMAC, which were recorded on a five-point Likert scale scoring, with a response of "none" scored as 0, "mild" as 1, "moderate" as 2, "severe" as 3 and "extreme" as 4.
次要结局
未报告次要终点