Analysis of Volatile Organic Compounds by Electronic Noses in Hospitalised Patients for an Infection by SARS-COV-2 (COVID-19)

Not Applicable

Completed

• Conditions: COVID-19
• Interventions: Device: Volatile Organic Compounds analysis

• Registration Number: NCT04379154
• Lead Sponsor: Hopital Foch

Brief Summary

The study of volatile organic compounds (VOCs) detected in exhaled air is an innovative research area for respiratory diseases. This analysis can be done by the technique of electronic nose, simpler and faster, which provides an idea of the general profile of the VOCs without identifying them. The VOCs in exhaled air in patients hospitalized for COVID-19 infection are analysed in this study, using electronic noses.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-14
• Study First Submitted: 2020-04-28
• Study First Submitted QC: 2020-05-06
• Study First Posted: 2020-05-07
• Primary Completion: 2021-06-01
• Study Completion: 2021-06-01
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-12
• Last Update Posted: 2022-01-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Patients infected by SARS-CoV-2 whose medical condition warrants hospitalisation (out of intensive care) for oxygen therapy less or equal to 4 l/min
• Patients must be 18 years of age or older
• Fluent in the French language
• Have signed a consent form
• Being affiliated with healthcare insurance

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Exclusion Criteria

• Pregnant woman
• Patient deprived of liberty by judicial or administrative decision

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Volatile Organic Compounds analysis	Volatile Organic Compounds analysis	Volatile Organic Compounds analysis in exhaled air in patients hospitalised for COVID-19 infection

Primary Outcome Measures

Name	Time	Method
Profiles of volatile organic compounds (VOCs) in exhaled air between 2 health conditions	1 day	Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from electronic noses (a set of sensors interacting with the VOCs exhaled). The analysis of the generated signal (resistance or load variations) is characteristic of the composition of VOCs), between patients who improve and patients who get worse during their hospitalisation for COVID-19 infection

Secondary Outcome Measures

Name	Time	Method
Profiles of volatile organic compounds (VOCs) in exhaled air between 2 periods	4 months	Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from electronic noses (a set of sensors interacting with the VOCs exhaled. The analysis of the generated signal (resistance or load variations) is characteristic of the composition of VOCs), between the hospitalisation period and a post-hospitalisation follow-up consultation in patients infected by COVID-19 and recovered.
Profiles of volatile organic compounds (VOCs) in exhaled air on 1 health condition	2 weeks	Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from electronic noses (a set of sensors interacting with the VOCs exhaled. The analysis of the generated signal (resistance or load variations) is characteristic of the composition of VOCs), between the start and the discharge to the hospital in patients infecting and recovering from COVID-19.
Profiles of volatile organic compounds (VOCs) in exhaled air by mass spectrometry at each visit based on patient evolution status.	4 months	Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from mass spectrometry, at hospitalisation, post-hospitalisation and follow-up consultation in patients infected by COVID-19 and recovered.

Trial Locations

Locations (1)

Hôpital Foch; 🇫🇷 Suresnes, France