A Clinical Study to Evaluate the Efficacy and Safety of a Polyherbal Unani Formulation in the Management of Zayabitus Sukkari Qism Sani (Diabetes Mellitus Type 2)

Diabetes mellitus is a metabolic disorders of multiple etiology, characterized by hyperglycemia with disturbance of carbohydrates, fats, and protein metabolism resulting from defects in insulin secretion and insulin action. The cost of diabetes care is high and is escalating worldwide. It is estimated 673 billion USD spent due to diabetes (2). The number of people withdiabetes mellitus is increasing in every country, half of the people with diabetes mellitus do not know they have it. It is estimated by International Diabetes Federation (IDF) that193 million people with diabetes are undiagnosed and are therefore more at risk of developing complications. One in 15 adults is estimated to have glucose tolerance, and one in 7th birth is affected by gestational diabetes mellitus (GDM). Number of men was affected 215.2 million and women 199.5 million in 2015, half of the people who die from diabetes mellitus are under the age of 60 year. This disorder is frequently associated with long term complication such as atherosclerosis Ischemic Heart Disease (IHD) Chronic renal failure, diabetes ketoacidosis. Worldwide prevalence of diabetes was estimated to 415 million in 2015 but in India alone 69.1 million and in China 114 million people. On account of its complication, it is leading cause of morbidity and mortality. Due to these complications, diabetes mellitus has become global problem despite of advancement of modern science. Several anti-diabetics agents are already being used such as glibenclamide,gliclazide, glimepiride, metformin, etc. But these drugs are associated with certain side effects like purpura, disulfiram-like reaction, flu like symptoms, lactic acidosis, hepatic dysfunction.

There are a number of classical compound formulations used for the management of Diabetes Mellitus in Unani system of medicine. To validate safety and efficacy of a polyherbal formulation comprising Gurmarbuti, Gilo Khushkand Maghz TukhmJamun, the present study entitled “**A Clinical Study to Evaluate the Efficacy and Safety of a Polyherbal Unani Formulation in the Management of Zayabitus Sukkari Qism Sani (Diabetes Mellitus Type 2)â€**has been designed.