Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Brain activity
研究概览
简要总结
This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.
详细描述
This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinically determined to require an awake left temporal resection of a brain lesion with concurrent language testing.
- •English as a first language.
排除标准
- •Significant preoperative neuropsychological deficits in memory or naming.
- •Patients with inability to make decisions regarding their participation in this research project.
- •Surgeon does not plan to expose the area of interest or determines that recording during the resection will interfere with his surgical plan.
研究组 & 干预措施
Concept Retrieval
Patients will be given behavioral intervention, and their brain activity recorded.
干预措施: Concepts (Behavioral)
结局指标
主要结局
Brain activity
时间窗: Recorded immediately during experiment
Electrocorticographic brain activity measured from brain surface
次要结局
未报告次要终点
研究者
William L Gross, MD PhD
Assistant Professor
Medical College of Wisconsin