Will prophylactic antibiotics in out of hospital cardiac arrest survivors receiving targeted temperature management prevent poor outcomes

Not Applicable

Recruiting

• Conditions: Out of hospital cardiac arrest; Circulatory System

• Registration Number: ISRCTN12258520
• Lead Sponsor: niversity Health Network

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-02-22
• Last Update Posted: 2 October 2017

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Age >18 years
2. Out-of-hospital cardiac arrest with ROSC
3. Glasgow coma scale <8 at time of hospital admission
4. Treated with TTM 32-34 degrees Celsius
5. Delay from ROSC to randomization <6 hours
6. Consent from substitute decision maker (SDM)

Exclusion Criteria

1. In hospital cardiac arrest
2. Ongoing antibiotic use for other infection prior to hospitalization (up to 1 week prior)
3. Diagnosis of pneumonia or sepsis prior to hospitalization
4. Non-cardiac illness that is immediate threat to life (i.e. intracranial hemorrhage, perforated viscus etc.).
5. Pregnancy
6. Known anaphylactic reaction to antibiotic used in study

Study & Design

• Study Type: Interventional
• Study Design: Not specified