Efficacy of Probiotics as an Adjunct to Standard Therapy in Androgenetic Alopecia(HAIR loss) : RCT (PRO- HAIR study )

Androgenetic alopecia, also known as male or female pattern hair loss, is the most common type of hair loss, affecting up to 80% of men and 50% of women by the age of 70. It is caused by a combination of genetics and hormones, especially a form of testosterone called dihydrotestosterone. Current treatments such as topical minoxidil, oral finasteride, platelet-rich plasma injections, and growth factor therapies mainly work at the scalp level but may not address deeper body-wide issues.

Recent research has shown that gut health may play a role in hair growth. An imbalance in gut bacteria—called dysbiosis—has been linked to several skin and hair problems.Probiotics, which are beneficial bacteria, may help improve hair condition by restoring gut balance, reducing inflammation, and improving nutrient absorption.

This study will explore whether taking probiotics alongside standard hair loss treatments can improve hair growth and patient satisfaction. It will also examine changes in gut bacteria before and after treatment, to see if any patterns are linked with better outcomes.

This study may significantly impact the management paradigm of androgenetic alopecia by validating the clinical utility of probiotics as a systemic adjunct.

By profiling gut microbiota and correlating it with hair parameters and treatment responses, the study also contributes to the growing field of personalized medicine. Identifying microbial biomarkers for prognosis or therapeutic success could open doors to precision-targeted interventions in AGA and related conditions.